User profiles for J. Axelrod

Jeffrey D Axelrod

Stanford
Verified email at stanford.edu
Cited by 11974

Stress hormones: their interaction and regulation

J Axelrod, TD Reisine - Science, 1984 - science.org
Stress stimulates several adaptive hormonal responses. Prominent among these responses
are the secretion of catecholamines from the adrenal medulla, corticosteroids from the …

[PDF][PDF] A second canon: functions and mechanisms of β-catenin-independent Wnt signaling

MT Veeman, JD Axelrod, RT Moon - Developmental cell, 2003 - cell.com
More is becoming known about so-called noncanonical Wnt pathways that signal
independently of β-catenin. Here we review recent developments in both the functions and …

The Pineal Gland: A Neurochemical Transducer: Chemical signals from nerves regulate synthesis of melatonin and convey information about internal clocks.

J Axelrod - Science, 1974 - science.org
The pineal gland has become the subject of considerable investigation during the past
decade because it provides a productive experimental model for studying circadian rhythms …

Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants

…, M Grimaldi, J Axelrod… - Proceedings of the …, 1998 - National Acad Sciences
The neuroprotective actions of cannabidiol and other cannabinoids were examined in rat
cortical neuron cultures exposed to toxic levels of the excitatory neurotransmitter glutamate. …

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

JD Axelrod, JR Miller, JM Shulman… - Genes & …, 1998 - genesdev.cshlp.org
In Drosophila, planar cell polarity (PCP) signaling is mediated by the receptor Frizzled (Fz)
and transduced by Dishevelled (Dsh). Wingless (Wg) signaling also requires Dsh and may …

Phospholipid methylation and biological signal transmission

F Hirata, J Axelrod - Science, 1980 - science.org
… Hirata is a visiting scientist and J. Axelrod is Chief of the Section on Pharmacology, Laboratory
of Clinical Science, National Institute of Mental Health, … Fusao Hirata and Julius Axelrod

Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.

CC Felder, EM Briley, J Axelrod… - Proceedings of the …, 1993 - National Acad Sciences
Arachidonylethanolamide (anandamide), a candidate endogenous cannabinoid ligand, has
recently been isolated from porcine brain and displayed cannabinoid-like binding activity to …

Control of enzymatic synthesis of adrenaline in the adrenal medulla by adrenal cortical steroids

RJ Wurtman, J Axelrod - Journal of Biological Chemistry, 1966 - ASBMB
The activity of phenylethanolamine N-methyltransferase, the enzyme that catalyzes the N-methylation
of noradrenaline to form adrenaline, falls following hypophysectomy. Enzyme …

Melatonin synthesis in the pineal gland: control by light

RJ Wurtman, J Axelrod, LS Phillips - Science, 1963 - science.org
In rats placed in continuous darkness for 6 days, there is a striking increase in the activity of
melatonin-synthesizing-enzyme (hydroxyindole-O-methyl transferase) in the pineal gland, …

Inhibition of uptake of tritiated-noradrenaline in the intact rat brain by imipramine and structurally related compounds

J Glowinski, J Axelrod - Nature, 1964 - nature.com
IMIPRAMINE is one of the most effective drugs for the alleviation of mental depression. There
is little information concerning the mechanism of action of this drug at the biochemical level…