Background Chronic psychological stress is associated with accelerated aging and increased
risk for aging-related diseases, but the underlying molecular mechanisms are unclear. …

N 6 -methyladenosine (m 6 A) and N 6 ,2′-O-dimethyladenosine (m 6 Am) are abundant
mRNA modifications that regulate transcript processing and translation. The role of both, here …

Aging and psychosocial stress are associated with increased inflammation and disease risk,
but the underlying molecular mechanisms are unclear. Because both aging and stress are …

Although gene expression profiles in peripheral blood in major depression are not likely to
identify genes directly involved in the pathomechanism of affective disorders, they may serve …

Prenatal stress exposure is associated with risk for psychiatric disorders later in life. This may
be mediated in part via enhanced exposure to glucocorticoids (GCs), which are known to …

Importance Observational studies highlight associations of C-reactive protein (CRP), a general
marker of inflammation, and interleukin 6 (IL-6), a cytokine-stimulating CRP production, …

We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS)
susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to associations …

Chronic stress is a major risk factor for depression. Interestingly, not all individuals develop
psychopathology after chronic stress exposure. In contrast to the prevailing view that stress …

Depression risk is exacerbated by genetic factors and stress exposure; however, the biological
mechanisms through which these factors interact to confer depression risk are poorly …

Objective: A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ
formation, with disturbances influencing many health outcomes. In utero, glucocorticoids …