User profiles for J. T. Wade

Joseph Wade

Wadsworth Center
Verified email at health.ny.gov
Cited by 5317

Pervasive transcription: illuminating the dark matter of bacterial transcriptomes

JT Wade, DC Grainger - Nature Reviews Microbiology, 2014 - nature.com
The conventional view of transcription posits that mRNAs are generated from the coding
DNA strand and are delineated by gene boundaries; however, recent reports have mapped …

[HTML][HTML] Leaderless transcripts and small proteins are common features of the mycobacterial translational landscape

…, TR Ioerger, SM Fortune, KM Derbyshire, JT Wade… - PLoS …, 2015 - journals.plos.org
RNA-seq technologies have provided significant insight into the transcription networks of
mycobacteria. However, such studies provide no definitive information on the translational …

The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes

JT Wade, DB Hall, K Struhl - Nature, 2004 - nature.com
Ribosomal protein (RP) genes in eukaryotes are coordinately regulated in response to growth
stimuli and environmental stress, thereby permitting cells to adjust ribosome number and …

[PDF][PDF] The transition between transcriptional initiation and elongation in E. coli is highly variable and often rate limiting

NB Reppas, JT Wade, GM Church, K Struhl - Molecular cell, 2006 - cell.com
We perform a genome-wide analysis of the transition between transcriptional initiation and
elongation in Escherichia coli by determining the association of core RNA polymerase (RNAP…

Widespread antisense transcription in Escherichia coli

JE Dornenburg, AM DeVita, MJ Palumbo, JT Wade - MBio, 2010 - Am Soc Microbiol
The vast majority of annotated transcripts in bacteria are mRNAs. Here we identify ~1,000
antisense transcripts in the model bacterium Escherichia coli . We propose that these …

[PDF][PDF] A 3′ external transcribed spacer in a tRNA transcript acts as a sponge for small RNAs to prevent transcriptional noise

…, MC Carrier, S Semsey, JS Brouard, J Wang, JT Wade… - Molecular cell, 2015 - cell.com
During ribosomal and transfer RNA maturation, external transcribed spacer (ETS) and internal
transcribed spacer (ITS) sequences are excised and, as non-functional by-products, are …

[HTML][HTML] Comprehensive Mapping of the Escherichia coli Flagellar Regulatory Network

DM Fitzgerald, RP Bonocora, JT Wade - PLoS genetics, 2014 - journals.plos.org
Flagellar synthesis is a highly regulated process in all motile bacteria. In Escherichia coli
and related species, the transcription factor FlhDC is the master regulator of a multi-tiered …

Extensive functional overlap between σ factors in Escherichia coli

JT Wade, DC Roa, DC Grainger, D Hurd… - Nature structural & …, 2006 - nature.com
Bacterial core RNA polymerase (RNAP) must associate with a σ factor to recognize promoter
sequences. Escherichia coli encodes seven σ factors, each believed to be specific for a …

Redefining fundamental concepts of transcription initiation in bacteria

C Mejía-Almonte, SJW Busby, JT Wade… - Nature Reviews …, 2020 - nature.com
Despite enormous progress in understanding the fundamentals of bacterial gene regulation,
our knowledge remains limited when compared with the number of bacterial genomes and …

An HMG Protein, Hmo1, Associates with Promoters of Many Ribosomal Protein Genes and throughout the rRNA Gene Locus in Saccharomyces cerevisiae

DB Hall, JT Wade, K Struhl - Molecular and cellular biology, 2006 - Taylor & Francis
… In addition, Ifh1 may also connect RP gene and rRNA transcription, as it forms a complex
with the rRNA processing factor Utp22 (Citation15; JT Wade and K. Struhl, unpublished data). …