[HTML][HTML] Adenovirus-associated virus vector–mediated gene transfer in hemophilia B
…, F Mingozzi, KA High, JT Gray… - … England Journal of …, 2011 - Mass Medical Soc
Background Hemophilia B, an X-linked disorder, is ideally suited for gene therapy. We
investigated the use of a new gene therapy in patients with the disorder. Methods We infused a …
investigated the use of a new gene therapy in patients with the disorder. Methods We infused a …
[HTML][HTML] Long-term safety and efficacy of factor IX gene therapy in hemophilia B
…, J Zhou, M Cancio, CL Morton, JT Gray… - … England Journal of …, 2014 - Mass Medical Soc
Background In patients with severe hemophilia B, gene therapy that is mediated by a novel
self-complementary adeno-associated virus serotype 8 (AAV8) vector has been shown to …
self-complementary adeno-associated virus serotype 8 (AAV8) vector has been shown to …
Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine …
AC Nathwani, JT Gray, CYC Ng, J Zhou, Y Spence… - Blood, 2006 - ashpublications.org
Transduction with recombinant adeno-associated virus (AAV) vectors is limited by the need
to convert its single-stranded (ss) genome to transcriptionally active double-stranded (ds) …
to convert its single-stranded (ss) genome to transcriptionally active double-stranded (ds) …
Two-year-old talk about the past
R Fivush, JT Gray, FA Fromhoff - Cognitive development, 1987 - Elsevier
… We are currently pursuing this line of investigation (Gray & Fivush, 1987). A second reason
why some events may be recalled in a narrative form has to do with how the event has been …
why some events may be recalled in a narrative form has to do with how the event has been …
[HTML][HTML] Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 …
…, M Valentine, J Allay, J Coleman, S Sleep, JT Gray… - Molecular therapy, 2011 - cell.com
Adeno-associated virus vectors (AAV) show promise for liver-targeted gene therapy. In this
study, we examined the long-term consequences of a single intravenous administration of a …
study, we examined the long-term consequences of a single intravenous administration of a …
Exogenous control of mammalian gene expression through modulation of RNA self-cleavage
L Yen, J Svendsen, JS Lee, JT Gray, M Magnier… - Nature, 2004 - nature.com
Recent studies on the control of specific metabolic pathways in bacteria have documented
the existence of entirely RNA-based mechanisms for controlling gene expression. These …
the existence of entirely RNA-based mechanisms for controlling gene expression. These …
Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in …
AC Nathwani, JT Gray, J McIntosh, CYC Ng, J Zhou… - Blood, 2007 - ashpublications.org
The safety and efficacy of peripheral venous administration of a self-complementary adeno-associated
viral vector encoding the human FIX gene (scAAV-LP1-hFIXco) was evaluated in …
viral vector encoding the human FIX gene (scAAV-LP1-hFIXco) was evaluated in …
Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency
…, E Kang, C Hadigan, M Meagher, JT Gray… - Science translational …, 2016 - science.org
X-linked severe combined immunodeficiency (SCID-X1) is a profound deficiency of T, B, and
natural killer (NK) cell immunity caused by mutations in IL2RG encoding the common chain …
natural killer (NK) cell immunity caused by mutations in IL2RG encoding the common chain …
Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant
…, S Waddington, AW Nienhuis, JT Gray… - Blood, The Journal …, 2013 - ashpublications.org
Recombinant adeno-associated virus (rAAV) vectors encoding human factor VIII (hFVIII)
were systematically evaluated for hemophilia A (HA) gene therapy. A 5.7-kb rAAV-expression …
were systematically evaluated for hemophilia A (HA) gene therapy. A 5.7-kb rAAV-expression …
[HTML][HTML] Long-term effects of feeding monensin on methane production in lactating dairy cows
…, P Dick, MM Or-Rashid, SE Hook, JT Gray… - Journal of Dairy …, 2007 - Elsevier
The objective of this study was to determine the long-term effects of feeding monensin on
methane (CH 4 ) production in lactating dairy cows. Twenty-four lactating Holstein dairy cows (…
methane (CH 4 ) production in lactating dairy cows. Twenty-four lactating Holstein dairy cows (…