To resolve cellular heterogeneity, we developed a combinatorial indexing strategy to profile
the transcriptomes of single cells or nuclei, termed sci-RNA-seq (single-cell combinatorial …

… JS is an investigator of the Howard Hughes Medical Institute. Author contributions: JS
and CT designed and supervised the research; JC developed techniques and performed …

Background Elucidation of the genetic factors underlying chronic liver disease may reveal
new therapeutic targets. Methods We used exome sequence data and electronic health …

Linking regulatory DNA elements to their target genes, which may be located hundreds of
kilobases away, remains challenging. Here, we introduce Cicero, an algorithm that identifies co…

INTRODUCTION Large-scale genetic studies of integrated health care populations, with
phenotypic data captured natively in the documentation of clinical care, have the potential to …

… SRS, MCR, CT, KRS, and JS wrote the manuscript with input from all authors. KRS, JS, and
CT supervised the project. Competing interests: One or more embodiments of one or more …

… We found that the Jensen-Shannon (JS) distance, a measure of transcriptome difference,
between the transcriptomes of posterior BWM (C lineage) versus both the first and second rows …

10.7554/eLife.45181.001 Thyroid hormone (TH) regulates diverse developmental events and
can drive disparate cellular outcomes. In zebrafish, TH has opposite effects on neural crest …

Motivation: Several algorithms exist for detecting copy number variants (CNVs) from human
exome sequencing read depth, but previous tools have not been well suited for large …

Background : Despite advances in treatment, mortality in acute myocardial infarction (AMI)
complicated by cardiogenic shock (CS) remains high. Short-term mechanical circulatory …