User profiles for J. R. Spence

Jason R. Spence

- Verified email at umich.edu - Cited by 19049

John Spence

- Verified email at ualberta.ca - Cited by 12856

Malignancies in bladder augmentations and intestinal conduits

RB Filmer, JR Spencer - The Journal of urology, 1990 - Elsevier
… W., Uehling, DT and Starling, JR: Cancer surveillance after ureterosigmoidostomy: colonic
… N., Narayana, AS, Sullivan, JW and Fraumeni, JF, Jr.: Urinary tract infection and risk of …

[HTML][HTML] Organoid models of human gastrointestinal development and disease

PH Dedhia, N Bertaux-Skeirik, Y Zavros, JR Spence - Gastroenterology, 2016 - Elsevier
We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent
stem cell–derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to …

Vertebrate intestinal endoderm development

JR Spence, R Lauf, NF Shroyer - Developmental dynamics, 2011 - Wiley Online Library
The endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as
associated organs. To generate a functional intestine, a series of highly orchestrated …

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

JR Spence, CN Mayhew, SA Rankin, MF Kuhar… - Nature, 2011 - nature.com
Studies in embryonic development have guided successful efforts to direct the differentiation
of human embryonic and induced pluripotent stem cells (PSCs) into specific organ cell …

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

…, BE Rockich, YH Tsai, CN Mayhew, JR Spence… - Nature, 2014 - nature.com
Gastric diseases, including peptic ulcer disease and gastric cancer, affect 10% of the world’s
population and are largely due to chronic Helicobacter pylori infection 1 , 2 , 3 . Species …

In vitro generation of human pluripotent stem cell derived lung organoids

…, R Nattiv, OD Klein, ES White, GH Deutsch, JR Spence - elife, 2015 - elifesciences.org
10.7554/eLife.05098.001 Recent breakthroughs in 3-dimensional (3D) organoid cultures for
many organ systems have led to new physiologically complex in vitro models to study …

Sampling carabid assemblages with pitfall traps: the madness and the method

JR Spence, JK Niemelä - The Canadian Entomologist, 1994 - cambridge.org
… Fournier, MB Spence, and DH Spence for assistance in the field, JS Scott for preparing the
… Niemela, J., JR Spence, and DH Spence. 1992. Habitat associations and seasonal activity …

An in vivo model of human small intestine using pluripotent stem cells

…, Y Sun, G Grabowski, SR Finkbeiner, JR Spence… - Nature medicine, 2014 - nature.com
Differentiation of human pluripotent stem cells (hPSCs) into organ-specific subtypes offers
an exciting avenue for the study of embryonic development and disease processes, for …

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

…, JR Spence, JF Engelhardt, RC Boucher, JR Rock… - Nature, 2022 - nature.com
Mapping the spatial distribution and molecular identity of constituent cells is essential for
understanding tissue dynamics in health and disease. We lack a comprehensive map of human …

Facile isolation and the characterization of human retinal stem cells

…, K Del Rio-Tsonis, JR Spence… - Proceedings of the …, 2004 - National Acad Sciences
This study identifies and characterizes retinal stem cells (RSCs) in early postnatal to seventh-decade
human eyes. Different subregions of human eyes were dissociated and cultured by …