Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide
variation from this region remain largely uncharacterized. We studied genomic …

Race and Genetic Ancestry in Medicine US health inequities won’t be eliminated by
abandoning the use of race and ethnicity in research and clinical practice, since these variables …

Rationale: Independent replication of genetic associations in complex diseases, particularly
in whole-genome association studies, is critical to confirm the association. Objectives: A …

Background Asthma is a complex disease with both genetic and environmental causes.
Genome-wide association studies of asthma have mostly involved European populations, and …

Latinos are the largest minority population in the United States. Although usually classified
as a single ethnic group by researchers, Latinos are heterogeneous from cultural, …

Background The primary rescue medication to treat acute asthma exacerbation is the short-acting
β 2 -adrenergic receptor agonist; however, there is variation in how well a patient …

Rationale: Air pollution is a known asthma trigger and has been associated with short-term
asthma symptoms, airway inflammation, decreased lung function, and reduced response to …

Genomic imprinting is an important regulatory mechanism that silences one of the parental
copies of a gene. To systematically characterize this phenomenon, we analyze tissue …

Background: In the United States, Puerto Ricans and Mexicans have the highest and lowest
asthma prevalence, morbidity, and mortality, respectively. Ethnic-specific differences in the …

10.7554/eLife.20532.001 Populations are often divided categorically into distinct racial/ethnic
groups based on social rather than biological constructs. Genetic ancestry has been …