Background: Developmental periods in early life may be particularly vulnerable to impacts
of environmental exposures. Human research on this topic has generally focused on single …

Copy number variation (CNV) of DNA sequences is functionally significant but has yet to be
fully ascertained. We have constructed a first-generation CNV map of the human genome …

Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

The popularization of large-scale genotyping projects has led to the widespread adoption of
genetic association studies as the tool of choice in the search for single nucleotide …

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide
association studies, we observed large chromosomal abnormalities in a subset of clones in …

BACKGROUND: There is an increasing recognition that the pathophysiology of mental disorders
could be the result of deregulation of synaptic plasticity with alterations of neurotrophins…

Down’s syndrome (DS) is a major cause of mental retardation, hypotonia and delayed
development. Murine models of DS carrying large murine or human genomic fragments show …

This paper provides a survey of the research done on optimization in dynamic environments
over the past decade. We show an analysis of the most commonly used problems, methods …

Biological entities (ranging from bacteria to humans) can engage in many and varied types
of social interaction, from altruistic cooperation to open conflict. A paradigmatic case of social …

Objective Through genome-wide association scans and meta-analyses thereof, over 70
genetic loci (Crohn's disease (CD) single nucleotide polymorphisms (SNPs)) are significantly …