Mutations affecting spliceosomal proteins are the most common mutations in patients with
myelodysplastic syndromes (MDS), but their role in MDS pathogenesis has not been …

Whole-exome sequencing studies have identified common mutations affecting genes
encoding components of the RNA splicing machinery in hematological malignancies. Here, we …

SF3B1 splicing factor mutations are near-universally found in myelodysplastic syndromes (MDS)
with ring sideroblasts (RS), a clonal hematopoietic disorder characterized by abnormal …

Substantial effort is currently devoted to identifying cancer-associated alterations using
genomics. Here, we show that standard blood collection procedures rapidly change the …

In spliceosomes, dynamic RNA/RNA and RNA/protein interactions position the pre-mRNA
substrate for the two chemical steps of splicing. Not all of these interactions have been …

A significant role of good user interface design is to enhance user experience. Keywords and
icons are heavily used in mobile applications because of the limited screen size and small …

Disaster is a complex problem that needs to be addressed using a multidimensional and
multiplatform framework in collecting information from disaster agents. Social media has been …

Isolating spliceosomes at a specific assembly stage requires a means to stall or enrich for
one of the intermediate splicing complexes. We describe strategies to arrest spliceosomes at …

Floods are the leading cause of natural disaster-related deaths worldwide. This study aimed
at assessing disaster preparedness and response by local Barangay (municipal) DRR (…

Spliceosomal mutations account for the most frequent class of mutations in patients with
MDS and CMML, yet the mechanism by which these mutations perform their driver function is …