User profiles for J. M. Simon

Jeremy M. Simon

Dana-Farber Cancer Institute, Harvard TH Chan School of Public Health
Verified email at ds.dfci.harvard.edu
Cited by 24182

[HTML][HTML] The accessible chromatin landscape of the human genome

…, A Safi, ME Sanchez, A Sanyal, A Shafer, JM Simon… - Nature, 2012 - nature.com
DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned
the discovery of all classes of cis-regulatory elements including enhancers, promoters, …

Use of mesenchymal stem cells (MSC) in chronic inflammatory fistulizing and fibrotic diseases: a comprehensive review

J Voswinkel, S Francois, JM Simon… - Clinical reviews in …, 2013 - Springer
Mesenchymal stem cells (MSC), multipotent adult stem cells, feature the potential to
regenerate tissue damage and, in parallel, inhibit inflammation and fibrosis. MSC can be safely …

Spinal metastases: indications for and results of percutaneous injection of acrylic surgical cement.

A Weill, J Chiras, JM Simon, M Rose, T Sola-Martinez… - Radiology, 1996 - pubs.rsna.org
PURPOSE: To determine the efficacy of percutaneous vertebroplasty in treating spinal
metastases that result in pain or instability. MATERIALS AND METHODS: Thirty-seven patients (…

70 Gy versus 80 Gy in localized prostate cancer: 5-year results of GETUG 06 randomized trial

…, JM Hannoun-Levi, L Malissard, JM Simon… - International Journal of …, 2011 - Elsevier
PURPOSE: To perform a randomized trial comparing 70 and 80 Gy radiotherapy for prostate
cancer. PATIENTS AND METHODS: A total of 306 patients with localized prostate cancer …

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

…, A Elkrief, RC Pezo, LE Haydu, JM Simon… - Nature medicine, 2021 - nature.com
Abstract Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and
PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-…

A map of open chromatin in human pancreatic islets

KJ Gaulton, T Nammo, L Pasquali, JM Simon… - Nature …, 2010 - nature.com
Tissue-specific transcriptional regulation is central to human disease 1 . To identify
regulatory DNA active in human pancreatic islets, we profiled chromatin by formaldehyde-assisted …

Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity

…, Y Shibata, KA Showers, JM Simon… - Genome …, 2011 - genome.cshlp.org
The human body contains thousands of unique cell types, each with specialized functions.
Cell identity is governed in large part by gene transcription programs, which are determined …

Using formaldehyde-assisted isolation of regulatory elements (FAIRE) to isolate active regulatory DNA

JM Simon, PG Giresi, IJ Davis, JD Lieb - Nature protocols, 2012 - nature.com
Eviction or destabilization of nucleosomes from chromatin is a hallmark of functional regulatory
elements in eukaryotic genomes. Historically identified by nuclease hypersensitivity, …

[PDF][PDF] Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions

…, AF Carpentier, F Laigle, JM Simon… - Journal of clinical …, 2004 - researchgate.net
Purpose To determine the response rate of low-grade oligodendroglial tumors (LGOT) to
temozolomide (TMZ) as initial treatment and to evaluate the predictive value of chromosome …

Temozolomide for low-grade gliomas: predictive impact of 1p/19q loss on response and outcome

…, S Paris, L Capelle, H Duffau, P Cornu, JM Simon… - Neurology, 2007 - AAN Enterprises
Objective: To evaluate the predictive impact of chromosome 1p/19q deletions on the response
and outcome of progressive low-grade gliomas (LGG) treated with up-front temozolomide (…