At the 67th Gerontological Society of America Annual Meeting, a preconference workshop
was convened to discuss the challenges of accurately assessing physical activity in older …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …

Background The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology
of cardiovascular disease, is among the most comprehensively characterized multi-…

Background— Visceral adipose tissue (VAT) compartments may confer increased metabolic
risk. The incremental utility of measuring both visceral and subcutaneous abdominal …

Background Heart failure is a major public health problem. Long-term trends in the incidence
of heart failure and survival after its onset in the community have not been characterized. …

Background— Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur
together, but there is limited information regarding their temporal relations and the combined …

Background— Congestive heart failure (CHF) is an increasing public health problem.
Methods and Results— Among Framingham Heart Study subjects who were free of CHF at …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Background DNA methylation levels change with age. Recent studies have identified
biomarkers of chronological age based on DNA methylation levels. It is not yet known whether …

Background— Excess adiposity is associated with greater systemic inflammation. Whether
visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is unclear…