Lentigo maligna is a melanocytic neoplasm occurring on sun-exposed skin, usually on the
head and neck, of middle-aged and elderly patients. It is thought to represent the in situ phase …

MODOMICS, a database devoted to the systems biology of RNA modification, has been
subjected to substantial improvements. It provides comprehensive information on the chemical …

Bax is required for the apoptotic death of sympathetic neurons deprived of nerve growth factor
(NGF). After NGF withdrawal, Bax translocates from the cytoplasm to the mitochondria of …

Aim: To clinically validate the 40-gene expression profile (40-GEP) test for cutaneous squamous
cell carcinoma patients and evaluate coupling the test with individual clinicopathologic …

Virtual screening (VS) overcomes the limitations of traditional high-throughput screening (HTS)
by applying computer-based methods in drug discovery. VS takes advantage of fast …

CCR4-NOT is a large protein complex present both in cytoplasm and the nucleus of eukaryotic
cells. Although it is involved in a variety of distinct processes related to expression of …

Pseudouridines in the stable RNAs of Bacteria are seldom subjected to further modification.
There are 11 pseudouridine (Ψ) sites in Escherichia coli rRNA, and further modification is …

Protein–RNA interactions play fundamental roles in many biological processes, such as
regulation of gene expression, RNA splicing, and protein synthesis. The understanding of these …

Purine nucleosides on position 9 of eukaryal and archaeal tRNAs are frequently modified in
vivo by the post-transcriptional addition of a methyl group on their N1 atom. The …

Background Dihydrouridine (D) is a modified base found in conserved positions in the D-loop
of tRNA in Bacteria, Eukaryota, and some Archaea. Despite the abundant occurrence of D, …