Wire Arc Additive Manufacturing (WAAM) is attracting significant attention in industry and
academia due to its ability to capture the benefits of additive manufacturing for production of …

Abstract Machines of protein destruction—including energy-dependent proteases and
disassembly chaperones of the AAA+ ATPase family—function in all kingdoms of life to sculpt the …

By synergistically combining additive and subtractive processes within a single workstation,
the relative merits of each process may be harnessed. This facilitates the manufacture of …

The accelerating pace of genome sequencing throughout the tree of life is driving the need
for improved unsupervised annotation of genome components such as transposable …

Titanium elastic nailing is used instead of traction and casting in many European centers,
but limited availability has prevented widespread use in North America. Before a planned …

Given its critical role in T-cell signaling, interleukin-2–inducible kinase (ITK) is an appealing
therapeutic target that can contribute to the pathogenesis of certain infectious, autoimmune, …

ClpXP is a protease involved in DNA damage repair, stationary-phase gene expression, and
ssrA-mediated protein quality control. To date, however, only a handful of ClpXP substrates …

Targeted therapy with imatinib in chronic myeloid leukemia (CML) prompted a new treatment
paradigm. Unlike CML, chronic lymphocytic leukemia (CLL) lacks an aberrant fusion …

We have simulated QCD using 2+ 1 flavors of domain wall quarks and the Iwasaki gauge
action on a (2.74 fm) 3 volume with an inverse lattice scale of a− 1= 1.729 (28) GeV. The up …

Importance The Bruton tyrosine kinase (BTK) inhibitor ibrutinib is effective in patients with
chronic lymphocytic leukemia (CLL). Reasons for discontinuing therapy with this drug and …