Background The full complement of DNA mutations that are responsible for the pathogenesis
of acute myeloid leukemia (AML) is not yet known. Methods We used massively parallel …

Massively parallel DNA sequencing technologies provide an unprecedented ability to
screen entire genomes for genetic changes associated with tumour progression. Here we …

CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in
Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of …

The Drug-Gene Interaction database (DGIdb) mines existing resources that generate
hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug …

The Drug–Gene Interaction Database (DGIdb, www.dgidb.org ) is a web resource that
consolidates disparate data sources describing drug–gene interactions and gene druggability. It …

Large-scale cancer sequencing data enable discovery of rare germline cancer susceptibility
variants. Here we systematically analyse 4,034 cases from The Cancer Genome Atlas …

In this work, we present the Genome Modeling System (GMS), an analysis information
management system capable of executing automated genome analysis pipelines at a massive …

The genomic events responsible for the pathogenesis of relapsed adult B-lymphoblastic
leukemia (B-ALL) are not yet clear. We performed integrative analysis of whole-genome, whole-…

Large-scale human genetics studies are now employing whole genome sequencing with the
goal of conducting comprehensive trait mapping analyses of all forms of genome variation. …

Malaria remains a threat to global health with 40% of the world's pregnant population at risk.
The disease has serious maternal and fetal implications. Obstetricians should be aware of …