[HTML][HTML] CCTop: an intuitive, flexible and reliable CRISPR/Cas9 target prediction tool
Engineering of the CRISPR/Cas9 system has opened a plethora of new opportunities for site-directed
mutagenesis and targeted genome modification. Fundamental to this is a stretch of …
mutagenesis and targeted genome modification. Fundamental to this is a stretch of …
Learning Bayesian networks by hill climbing: efficient methods based on progressive restriction of the neighborhood
Learning Bayesian networks is known to be an NP-hard problem and that is the reason why
the application of a heuristic search has proven advantageous in many domains. This …
the application of a heuristic search has proven advantageous in many domains. This …
Refined sgRNA efficacy prediction improves large-and small-scale CRISPR–Cas9 applications
…, EM Charpentier, A Schwarzer, JL Mateo… - Nucleic acids …, 2018 - academic.oup.com
Genome editing with the CRISPR–Cas9 system has enabled unprecedented efficacy for
reverse genetics and gene correction approaches. While off-target effects have been …
reverse genetics and gene correction approaches. While off-target effects have been …
Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence
The majority of neural stem cells (NSCs) in the adult brain are quiescent, and this fraction
increases with aging. Although signaling pathways that promote NSC quiescence have been …
increases with aging. Although signaling pathways that promote NSC quiescence have been …
Finding out general tendencies in speckle noise reduction in ultrasound images
JL Mateo, A Fernández-Caballero - Expert systems with applications, 2009 - Elsevier
This article investigates and compiles some of the techniques mostly used in the smoothing
or suppression of speckle noise in ultrasound images. With this information, a comparison of …
or suppression of speckle noise in ultrasound images. With this information, a comparison of …
Potential microplastics impacts on African fishing resources
Microplastic (MP) pollution is increasing worldwide and affecting aquatic fauna in different
ways, which endangers current aquatic resources in a still unknown extent. MP-induced …
ways, which endangers current aquatic resources in a still unknown extent. MP-induced …
Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal
JL Mateo, DLC van den Berg, M Haeussler… - Genome …, 2015 - genome.cshlp.org
The gene regulatory network (GRN) that supports neural stem cell (NS cell) self-renewal has
so far been poorly characterized. Knowledge of the central transcription factors (TFs), the …
so far been poorly characterized. Knowledge of the central transcription factors (TFs), the …
Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction
Single nucleotide variants (SNVs) are prevalent genetic factors shaping individual trait
profiles and disease susceptibility. The recent development and optimizations of base editors, …
profiles and disease susceptibility. The recent development and optimizations of base editors, …
[HTML][HTML] Depletion of key meiotic genes and transcriptome-wide abiotic stress reprogramming mark early preparatory events ahead of apomeiotic transition
…, O Kirioukhova, P Pawar, M Tayyab, JL Mateo… - Frontiers in plant …, 2016 - frontiersin.org
Molecular dissection of apomixis – an asexual reproductive mode – is anticipated to solve
the enigma of loss of meiotic sex, and to help fixing elite agronomic traits. The Brassicaceae …
the enigma of loss of meiotic sex, and to help fixing elite agronomic traits. The Brassicaceae …
Photochemistry and photopolymerization study on 2-acetoxy and methyl-2-acetoxy derivatives of thioxanthone as photoinitiators
…, JM Tercero, C Peinado, R Sastre, JL Mateo… - … of Photochemistry and …, 1989 - Elsevier
The initiation efficiencies of 2-acetoxy thioxanthone and its methyl derivatives (in the 1, 3
and 4 positions) were studied by photocalorimetry when they were used as photoinitiators in …
and 4 positions) were studied by photocalorimetry when they were used as photoinitiators in …