The RNA-guided nuclease Cas9 can be reengineered as a programmable transcription
factor. However, modest levels of gene activation have limited potential applications. We …

The Cas9 protein from the Streptococcus pyogenes CRISPR-Cas acquired immune system
has been adapted for both RNA-guided genome editing and gene regulation in a variety of …

Elucidating functions of commensal microbial genes in the mammalian gut is challenging
because many commensals are recalcitrant to laboratory cultivation and genetic manipulation. …

In light of the multitude of new Cas9-mediated functionalities, the ability to carry out multiple
Cas9-enabled processes simultaneously and in a single cell is becoming increasingly …

The relationship between patient-staff ratio and the prevalence of patient incidents, such as
assaults, fighting, suicides, falls, and abuse of patients by staff, was examined at an urban …

This protocol outlines a general approach for characterizing the protospacer-adjacent motifs
(PAMs) of Cas9 orthologs. It uses a three-plasmid system: One plasmid carries Cas9 and its …

This thesis offers an overview of a selection of the animal similes within the Odyssey and the
Agamemnon. I examine the ways in which the animal similes, reverse similes, and overall …

Background Schizophrenia patients exhibit cognitive deficits across multiple domains, including
verbal memory, working memory, and executive function, which substantially contribute …

… Braff at Cozen and O'Connor, The Atrium, 1900 Market Street, Philadelphia, PA 19103.
The Americans with Disabilities Act of 1990, 42 USC § 12101. The Federal Rehabilitation …

… BRAFF … BRAFF, JD, is also a member of the labor and employment department of
Cozen and O’Connor. Both devote much of their practice to preventive counseling and …