The physiological responses of cells to external and internal stimuli are governed by genes
and proteins interacting in complex networks whose dynamical properties are impossible to …

… An inhibitor-amplified negative-feedback loop (in which X is Cdc10, Y is Cig2 and Z is Rum1)
has been used by Novak and Tyson 49 to model endoreplication (periodic DNA synthesis …

Waves of chemical or electrical activity, traveling through space, have been observed in
several contexts: chemical reaction mixtures in non-convecting liquid phase, cell suspensions, …

The molecular machinery of cell cycle control is known in more detail for budding yeast,
Saccharomyces cerevisiae, than for any other eukaryotic organism. In recent years, many …

Complex assemblies of interacting proteins carry out most of the interesting jobs in a cell,
such as metabolism, DNA synthesis, movement and information processing. These …

… To determine whether hysteresis underlies entry into and exit from mitosis in cell-free egg
extracts, we tested three predictions of the Novak–Tyson model. (i) The minimal concentration …

… A more serious difficulty is that Tyson's echo waves in the Oregonator assume an oxidized
(blue) quiescent … There are no echo waves around a reduced steady state in Tyson's model. …

In 1958 BP Belousov discovered that the oxidation of citric acid by bromate in the presence
of cerium ions does not proceed to equilibrium methodically and uniformly, like most …

This text is an introduction to dynamical modeling in cell biology. It is not meant as a complete
overview of modeling or of particular models in cell biology. Rather, we use selected …

The adaptive responses of a living cell to internal and external signals are controlled by
networks of proteins whose interactions are so complex that the functional integration of the …