Human studies have firmly implicated voltage-gated sodium channels in human pain
disorders, and targeted and massively parallel genomic sequencing is beginning to be used in …

Background Maternal hypotension is the most frequent complication of spinal anaesthesia
for caesarean section. It can be associated with nausea or vomiting and may pose serious …

ObjectiveTo provide evidence-based consensus guidelines for the management of women
with cervical cytological abnormalities and cervical cancer precursors.ParticipantsA panel of …

The complete inability to sense pain in an otherwise healthy individual is a very rare phenotype.
In three consanguineous families from northern Pakistan, we mapped the condition as …

Nurr1 is a member of the nuclear receptor superfamily of transcription factors that is
expressed predominantly in the central nervous system, including developing and mature …

The neurotrophin brain-derived neurotrophic factor (BDNF) inhibits food intake, and rodent
models of BDNF disruption all exhibit increased food intake and obesity, as well as …

Human monogenic pain syndromes have provided important insights into the molecular
mechanisms that underlie normal and pathological pain states. We describe an autosomal-…

The mesencephalic dopaminergic (mesDA) system regulates behavior and movement control
and has been implicated in psychiatric and affective disorders. We have identified a bicoid-…

We identified the LIM homeodomain transcription factor Lmx1b in the mesencephalic
dopamine (mesDA) systems of embryos and adults. Analysis of spatiotemporal expression in …

The gene SCN9A is responsible for three human pain disorders. Nonsense mutations cause
a complete absence of pain, whereas activating mutations cause severe episodic pain in …