New cell lines from mouse epiblast share defining features with human embryonic stem cells
PJ Tesar, JG Chenoweth, FA Brook, TJ Davies… - Nature, 2007 - nature.com
The application of human embryonic stem (ES) cells in medicine and biology has an inherent
reliance on understanding the starting cell population. Human ES cells differ from mouse …
reliance on understanding the starting cell population. Human ES cells differ from mouse …
Regulation of transcriptional activation domain function by ubiquitin
SE Salghetti, AA Caudy, JG Chenoweth, WP Tansey - Science, 2001 - science.org
The ability of transcriptional activation domains (TADs) to signal ubiquitin-mediated proteolysis
suggests an involvement of the ubiquitin-proteasome pathway in transcription. To probe …
suggests an involvement of the ubiquitin-proteasome pathway in transcription. To probe …
[HTML][HTML] Identification and characterization of cell type–specific and ubiquitous chromatin regulatory structures in the human genome
The identification of regulatory elements from different cell types is necessary for understanding
the mechanisms controlling cell type–specific and housekeeping gene expression. …
the mechanisms controlling cell type–specific and housekeeping gene expression. …
[HTML][HTML] Rest repression of neuronal genes requires components of the hSWI· SNF complex
…, ME Andrés, DW Rose, JG Chenoweth… - Journal of Biological …, 2002 - ASBMB
A function of the transcription factor REST is to block the expression of neuronal phenotypic
traits in non-neuronal cells. Previous studies have shown that REST-mediated repression …
traits in non-neuronal cells. Previous studies have shown that REST-mediated repression …
[HTML][HTML] The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells
…, HH Chen, M Eijpe, A Yabuuchi, JG Chenoweth… - Cell, 2008 - cell.com
Pluripotent stem cell lines can be derived from blastocyst embryos, which yield embryonic
stem cell lines (ES cells), as well as the postimplantation epiblast, which gives rise to epiblast …
stem cell lines (ES cells), as well as the postimplantation epiblast, which gives rise to epiblast …
[PDF][PDF] Isolation of epiblast stem cells from preimplantation mouse embryos
FJ Najm, JG Chenoweth, PD Anderson, JH Nadeau… - Cell stem cell, 2011 - cell.com
Pluripotent stem cells provide a platform to interrogate control elements that function to generate
all cell types of the body. Despite their utility for modeling development and disease, the …
all cell types of the body. Despite their utility for modeling development and disease, the …
A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus
…, BJ Maher, NJ Brandon, A Cross, JG Chenoweth… - Nature medicine, 2016 - nature.com
Genome-wide association studies (GWASs) have reported many single nucleotide
polymorphisms (SNPs) associated with psychiatric disorders, but knowledge is lacking regarding …
polymorphisms (SNPs) associated with psychiatric disorders, but knowledge is lacking regarding …
Epiblast stem cells contribute new insight into pluripotency and gastrulation
JG Chenoweth, RDG McKay… - Development, growth & …, 2010 - Wiley Online Library
Gastrulation is the defining feature of metazoan development where it serves to apportion
seemingly equivalent, pluripotent cells to specific fates. The three embryonic germ layers …
seemingly equivalent, pluripotent cells to specific fates. The three embryonic germ layers …
[HTML][HTML] Epigenomic comparison reveals activation of “seed” enhancers during transition from naive to primed pluripotency
…, GE Zentner, A Saiakhova, L Song, JG Chenoweth… - Cell stem cell, 2014 - cell.com
Naive mouse embryonic stem cells (mESCs) and primed epiblast stem cells (mEpiSCs)
represent successive snapshots of pluripotency during embryogenesis. Using transcriptomic and …
represent successive snapshots of pluripotency during embryogenesis. Using transcriptomic and …
Direct and indirect contribution of human embryonic stem cell–derived hepatocyte-like cells to liver repair in mice
…, JH Lee, SH Hong, KW Song, EK Ahn, JG Chenoweth… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Many studies of embryonic stem cells have investigated direct cell
replacement of damaged tissues, but little is known about how donor cell–derived signals …
replacement of damaged tissues, but little is known about how donor cell–derived signals …