New cell lines from mouse epiblast share defining features with human embryonic stem cells

PJ Tesar, JG Chenoweth, FA Brook, TJ Davies… - Nature, 2007 - nature.com
The application of human embryonic stem (ES) cells in medicine and biology has an inherent
reliance on understanding the starting cell population. Human ES cells differ from mouse …

Regulation of transcriptional activation domain function by ubiquitin

SE Salghetti, AA Caudy, JG Chenoweth, WP Tansey - Science, 2001 - science.org
The ability of transcriptional activation domains (TADs) to signal ubiquitin-mediated proteolysis
suggests an involvement of the ubiquitin-proteasome pathway in transcription. To probe …

[HTML][HTML] Identification and characterization of cell type–specific and ubiquitous chromatin regulatory structures in the human genome

…, Y Fu, DM Bodine, RDG McKay, JG Chenoweth… - PLoS …, 2007 - journals.plos.org
The identification of regulatory elements from different cell types is necessary for understanding
the mechanisms controlling cell type–specific and housekeeping gene expression. …

[HTML][HTML] Rest repression of neuronal genes requires components of the hSWI· SNF complex

…, ME Andrés, DW Rose, JG Chenoweth… - Journal of Biological …, 2002 - ASBMB
A function of the transcription factor REST is to block the expression of neuronal phenotypic
traits in non-neuronal cells. Previous studies have shown that REST-mediated repression …

[HTML][HTML] The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells

…, HH Chen, M Eijpe, A Yabuuchi, JG Chenoweth… - Cell, 2008 - cell.com
Pluripotent stem cell lines can be derived from blastocyst embryos, which yield embryonic
stem cell lines (ES cells), as well as the postimplantation epiblast, which gives rise to epiblast …

[PDF][PDF] Isolation of epiblast stem cells from preimplantation mouse embryos

FJ Najm, JG Chenoweth, PD Anderson, JH Nadeau… - Cell stem cell, 2011 - cell.com
Pluripotent stem cells provide a platform to interrogate control elements that function to generate
all cell types of the body. Despite their utility for modeling development and disease, the …

A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus

…, BJ Maher, NJ Brandon, A Cross, JG Chenoweth… - Nature medicine, 2016 - nature.com
Genome-wide association studies (GWASs) have reported many single nucleotide
polymorphisms (SNPs) associated with psychiatric disorders, but knowledge is lacking regarding …

Epiblast stem cells contribute new insight into pluripotency and gastrulation

JG Chenoweth, RDG McKay… - Development, growth & …, 2010 - Wiley Online Library
Gastrulation is the defining feature of metazoan development where it serves to apportion
seemingly equivalent, pluripotent cells to specific fates. The three embryonic germ layers …

[HTML][HTML] Epigenomic comparison reveals activation of “seed” enhancers during transition from naive to primed pluripotency

…, GE Zentner, A Saiakhova, L Song, JG Chenoweth… - Cell stem cell, 2014 - cell.com
Naive mouse embryonic stem cells (mESCs) and primed epiblast stem cells (mEpiSCs)
represent successive snapshots of pluripotency during embryogenesis. Using transcriptomic and …

Direct and indirect contribution of human embryonic stem cell–derived hepatocyte-like cells to liver repair in mice

…, JH Lee, SH Hong, KW Song, EK Ahn, JG Chenoweth… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Many studies of embryonic stem cells have investigated direct cell
replacement of damaged tissues, but little is known about how donor cell–derived signals …