The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
We present the molecular landscape of pediatric acute myeloid leukemia (AML) and
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The COG–…
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The COG–…
Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia
JE Farrar, M Nater, E Caywood… - Blood, The Journal …, 2008 - ashpublications.org
Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome characterized
by anemia, congenital abnormalities, and cancer predisposition. Small ribosomal subunit …
by anemia, congenital abnormalities, and cancer predisposition. Small ribosomal subunit …
[PDF][PDF] Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia
…, M Matysiak, B Glader, RJ Arceci, JE Farrar… - The American Journal of …, 2010 - cell.com
Diamond-Blackfan anemia (DBA), an inherited bone marrow failure syndrome characterized
by anemia that usually presents before the first birthday or in early childhood, is associated …
by anemia that usually presents before the first birthday or in early childhood, is associated …
Genomic profiling of pediatric acute myeloid leukemia reveals a changing mutational landscape from disease diagnosis to relapse
The genomic and clinical information used to develop and implement therapeutic approaches
for acute myelogenous leukemia (AML) originated primarily from adult patients and has …
for acute myelogenous leukemia (AML) originated primarily from adult patients and has …
Ribosomal protein gene deletions in Diamond-Blackfan anemia
JE Farrar, A Vlachos, E Atsidaftos… - Blood, The Journal …, 2011 - ashpublications.org
Diamond-Blackfan anemia (DBA) is a congenital BM failure syndrome characterized by
hypoproliferative anemia, associated physical abnormalities, and a predisposition to cancer. …
hypoproliferative anemia, associated physical abnormalities, and a predisposition to cancer. …
[HTML][HTML] Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia
Relapsed or refractory pediatric acute myeloid leukemia (AML) is associated with poor
outcomes and relapse risk prediction approaches have not changed significantly in decades. To …
outcomes and relapse risk prediction approaches have not changed significantly in decades. To …
Coevolution of URAT1 and uricase during primate evolution: implications for serum urate homeostasis and gout
PK Tan, JE Farrar, EA Gaucher… - Molecular biology and …, 2016 - academic.oup.com
Uric acid is the highly insoluble end-product of purine metabolism in humans. Serum levels
exceeding the solubility threshold can trigger formation of urate crystals resulting in gouty …
exceeding the solubility threshold can trigger formation of urate crystals resulting in gouty …
Neutropenia in X-linked agammaglobulinemia
X-linked agammaglobulinemia (XLA) is usually considered a disorder of B cell development;
however, the gene that is defective in XLA encodes a cytoplasmic tyrosine kinase called Btk…
however, the gene that is defective in XLA encodes a cytoplasmic tyrosine kinase called Btk…
Comprehensive Transcriptome Profiling of Cryptic CBFA2T3–GLIS2 Fusion–Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML …
Purpose: A cryptic inv(16)(p13.3q24.3) encoding the CBFA2T3–GLIS2 fusion is associated
with poor outcome in infants with acute megakaryocytic leukemia. We aimed to broaden our …
with poor outcome in infants with acute megakaryocytic leukemia. We aimed to broaden our …
Exploiting pre‐rRNA processing in D iamond B lackfan anemia gene discovery and diagnosis
JE Farrar, P Quarello, R Fisher… - American journal of …, 2014 - Wiley Online Library
Diamond Blackfan anemia (DBA), a syndrome primarily characterized by anemia and physical
abnormalities, is one among a group of related inherited bone marrow failure syndromes (…
abnormalities, is one among a group of related inherited bone marrow failure syndromes (…