… Mutations in each genome were then identified using BRESEQ, a pipeline implemented in
Perl for analysing bacterial WGS re-sequencing data (JE Barrick, unpublished algorithm). The …

Next-generation DNA sequencing (NGS) can be used to reconstruct eco-evolutionary
population dynamics and to identify the genetic basis of adaptation in laboratory evolution …

Riboswitches are metabolite binding domains within certain messenger RNAs that serve as
precision sensors for their corresponding targets. Allosteric rearrangement of mRNA …

Genetic control by metabolite-binding mRNAs is widespread in prokaryotes. These riboswitches
are typically located in noncoding regions of mRNA, where they selectively bind their …

… Barrick, JE et al. Genome evolution and adaptation in a long-term experiment with …
Blount, ZD, Barrick, JE, Davidson, CJ & Lenski, RE Genomic analysis of a key innovation in an …

The outcomes of evolution are determined by a stochastic dynamical process that governs
how mutations arise and spread through a population. However, it is difficult to observe these …

Evolutionary novelties have been important in the history of life, but their origins are usually
difficult to examine in detail. We previously described the evolution of a novel trait, aerobic …

We identified a previously unknown riboswitch class in bacteria that is selectively triggered
by glycine. A representative of these glycine-sensing RNAs from Bacillus subtilis operates as …

The expression of certain genes involved in fundamental metabolism is regulated by
metabolite-binding “riboswitch” elements embedded within their corresponding mRNAs. We have …

Background Riboswitches are noncoding RNA structures that appropriately regulate genes
in response to changing cellular conditions. The expression of many proteins involved in …