Proteins requiring post‐translational modifications such as N‐linked glycosylation are
processed in the endoplasmic reticulum (ER). A diverse array of cellular stresses can lead to …

A growing body of evidence indicates that many cellular reactions within metabolic pathways
are catalyzed not by free-floating ‘soluble’ enzymes, but via one or more membrane-…

The role that mechanistic mathematical modeling and systems biology will play in molecular
medicine and clinical development remains uncertain. In this study, mathematical modeling …

Cell-free systems are a widely used research tool in systems and synthetic biology and a
promising platform for manufacturing of proteins and chemicals. In the past, cell-free biology …

The ubiquitin-proteasome pathway (UPP) is the main route of protein degradation in
eukaryotic cells and is a common mechanism through which numerous cellular pathways are …

Both physiological and pathological tissue remodeling (eg, during wound healing and
cancer, respectively) require new blood vessel formation via angiogenesis, but the underlying …

… In adapting the framework to a large network, Varner and Ramkrishna12, 13 developed an
… Varner15 used the methodology to simulate various features of E. coli metabolism. However…

Cell-free systems for gene expression have gained attention as platforms for the facile study
of genetic circuits and as highly effective tools for teaching. Despite recent progress, the …

In this study, we present an effective model All-Trans Retinoic Acid (ATRA)-induced
differentiation of HL-60 cells. The model describes reinforcing feedback between an ATRA-inducible …

A major objective of synthetic glycobiology is to re-engineer existing cellular glycosylation
pathways from the top down or construct non-natural ones from the bottom up for new and …