Single-cell RNA sequencing (scRNA-seq) can be used to characterize variation in gene
expression levels at high resolution. However, the sources of experimental noise in scRNA-seq …

DNA methylation is an important epigenetic regulator of gene expression. Recent studies
have revealed widespread associations between genetic variation and methylation levels. …

Many scientists write code as part of their research. Just as experiments are logged in
laboratory notebooks, it is important to document the code you use for analysis. However, a few …

10.7554/eLife.33480.001 Anthracycline-induced cardiotoxicity (ACT) is a key limiting factor
in setting optimal chemotherapy regimes, with almost half of patients expected to develop …

Cellular heterogeneity in gene expression is driven by cellular processes, such as cell cycle
and cell-type identity, and cellular environment such as spatial location. The cell cycle, in …

Quantification of gene expression levels at the single cell level has revealed that gene
expression can vary substantially even across a population of homogeneous cells. However, it is …

The innate immune system provides the first response to infection and is now recognized to
be partially pathogen-specific. Mycobacterium tuberculosis (MTB) is able to subvert the …

Making scientific analyses reproducible, well documented, and easily shareable is crucial to
maximizing their impact and ensuring that others can build on them. However, …

Background There is substantial interest in the evolutionary forces that shaped the regulatory
framework in early human development. Progress in this area has been slow because it is …

Tuberculosis (TB) is a deadly infectious disease, which kills millions of people every year.
The causative pathogen, Mycobacterium tuberculosis (MTB), is estimated to have infected up …