The development of highly effective and durable vaccines against the human malaria parasites
Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor have …

All the symptoms and pathology of malaria are caused by the intraerythrocytic stages of the
Plasmodium parasite life cycle. Because Plasmodium parasites cannot replicate outside a …

Post-translational modifications play crucial parts in regulating protein function and thereby
control several fundamental aspects of eukaryotic biology, including cell signalling, protein …

Erythrocyte invasion by Plasmodium falciparum is central to the pathogenesis of malaria.
Invasion requires a series of extracellular recognition events between erythrocyte receptors …

INTRODUCTION Malaria remains a devastating global parasitic disease, with the majority
of malaria deaths caused by the highly virulent Plasmodium falciparum. The extreme AT-bias …

Plasmodium falciparum is the most prevalent and lethal of the malaria parasites infecting
humans, yet the origin and evolutionary history of this important pathogen remain controversial. …

Malaria elimination strategies require surveillance of the parasite population for genetic
changes that demand a public health response, such as new forms of drug resistance 1 , 2 . …

We describe an analysis of genome variation in 825 P. falciparum samples from Asia and
Africa that identifies an unusual pattern of parasite population structure at the epicenter of …

The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and
novel modes of action, to widen the scope of treatment and to overcome emerging drug …