… influenzae genomes (JC Mell and RJ Redfield, unpublished data). This pattern could be
informative about the function of competence, since molecular drive predicts reduced variation …

Structural variation (SV) is a rich source of genetic diversity in mammals, but due to the
challenges associated with mapping SV in complex genomes, basic questions regarding their …

Background Lung cancer is the leading cancer diagnosis worldwide and the number one
cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer, …

A talented artist developed a progressive aphasia syndrome associated with frontotemporal
dementia (FTD). As her disease progressed, language and executive skills declined, but her …

Background Pan-bacterial 16S rRNA microbiome surveys performed with massively parallel
DNA sequencing technologies have transformed community microbiological studies. …

Many bacteria are able to efficiently bind and take up double-stranded DNA fragments, and
the resulting natural transformation shapes bacterial genomes, transmits antibiotic resistance…

Respiratory viral infections contribute substantially to global infant losses and disproportionately
affect preterm neonates. Using our previously established neonatal murine model of …

Chronic bacterial infections of the lung are the leading cause of morbidity and mortality in
cystic fibrosis patients. Tracking bacterial evolution during chronic infections can provide …

Natural competence is the ability of bacteria to actively take up extracellular DNA. This DNA
can recombine with the host chromosome, transforming the host cell and altering its …

Tracking bacterial evolution during chronic infection provides insights into how host
selection pressures shape bacterial genomes. The human-restricted opportunistic pathogen …