An enhanced Th2 immune response and the elaboration of cytokines such as IL-4, IL-13,
and IL-5 contribute to the induction of allergy and asthma. Interferon-γ, a Th1 cytokine, acts in …

Current evidence supports a role for gut colonization in promoting and maintaining a balanced
immune response in early life. An altered or less diverse gut microbiota composition has …

BACKGROUND AND OBJECTIVE: Environmental or lifestyle exposures in utero may influence
the development of childhood asthma. In this meta-analysis, we aimed to assess whether …

Rationale: Maternal vitamin D intake during pregnancy has been inversely associated with
asthma symptoms in early childhood. However, no study has examined the relationship …

Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

… Similarly, Celedon and coworkers found that increasing BMI was associated with an increased
risk of symptomatic AHR in a cross-sectional study of 7,109 Chinese adults (2). So, while …

Men have higher prevalence rates of chronic obstructive pulmonary disease (COPD) than
women, which has been attributed to the historically higher rates of cigarette smoking in males…

BACKGROUND: The mechanisms and consequences of the observed association between
obesity and childhood asthma are unclear. OBJECTIVES: We sought to determine the effect …

Asthma, a chronic airway disease with known heritability, affects more than 300 million
people around the world. A genome-wide association (GWA) study of asthma with 359 cases …

Common SNPs in the chromosome 17q12-q21 region alter the risk for asthma, type 1
diabetes, primary biliary cirrhosis, and Crohn disease. Previous reports by us and others have …