Monocytes/macrophages are critical in orchestrating the tissue-repair response. However, the
mechanisms that govern macrophage regenerative activities during the sequential phases …

Macrophages are present in all tissues, either as resident cells or monocyte-derived cells
that infiltrate into tissues. The tissue site largely determines the phenotype of tissue-resident …

Activation of the immune response during injury is a critical early event that determines whether
the outcome of tissue restoration is regeneration or replacement of the damaged tissue …

The type 2 immune response controls helminth infection and maintains tissue homeostasis
but can lead to allergy and fibrosis if not adequately regulated. We have discovered local …

The immune system has a well‐established contribution to tissue homeostasis and wound
healing. However, in many cases immune responses themselves can cause severe tissue …

Cellular forces are crucial for many biological processes but current methods to image them
have limitations with respect to data analysis, resolution and throughput. Here, we present a …

10.7554/eLife.30947.001 Both T H 2-dependent helminth killing and suppression of the T H
2 effector response have been attributed to macrophages (MΦ) activated by IL-4 (M(IL-4)). …

T cell-intrinsic regulation, such as anergy, adaptive tolerance and exhaustion, is central to
immune regulation. In contrast to Type 1 and Type 17 settings, knowledge of the intrinsic fate …

In this issue of Immunity, Kimball et al. (2019) show that restoring expression of the chromatin
modifying enzyme Setdb2 in macrophages rescues impaired wound healing associated …

Filarial helminths infect approximately 120 million people worldwide initiating a type 2
immune response in the host. Influenza A viruses stimulate a virulent type 1 pro-inflammatory …