In addition to its value in the study of molecular evolution, ancestral sequence reconstruction
(ASR) has emerged as a useful methodology for engineering proteins with enhanced …

Non-ribosomal peptide synthetases are important enzymes for the assembly of complex
peptide natural products. Within these multi-modular assembly lines, condensation domains …

The improved production, recycling, and removal of plastic waste, such as polyethylene
terephthalate (PET), are pressing environmental and economic issues for society. Biocatalytic (…

The emergence of enzymes through the neofunctionalization of noncatalytic proteins is
ultimately responsible for the extraordinary range of biological catalysts observed in nature. …

Kistamicin is a divergent member of the glycopeptide antibiotics, a structurally complex
class of important, clinically relevant antibiotics often used as the last resort against resistant …

Several enzymes are known to have evolved from non-catalytic proteins such as solute-binding
proteins (SBPs). Although attention has been focused on how a binding site can evolve …

The contact system comprises a series of serine proteases that mediate procoagulant and
proinflammatory activities via the intrinsic pathway of coagulation and the kallikrein–kinin …

The repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) is a major
vaccine antigen because it can be targeted by parasite neutralizing antibodies; however, little …

Antibodies targeting the NANP/NVDP repeat domain of the Plasmodium falciparum
circumsporozoite protein (CSP Repeat ) can protect against malaria. However, it has also been …

Cyanobacteria have evolved a suite of enzymes and inorganic carbon (C i ) transporters
that improve photosynthetic performance by increasing the localized concentration of CO 2 …