User profiles for J. A. Haltom

Jeffrey Haltom

Children's Hospital of Philadelphia
Verified email at chop.edu
Cited by 201

Efficient targeted integration directed by short homology in zebrafish and mammalian cells

…, Z Ming, A Wehmeier, CS Mikelson, JA Haltom… - Elife, 2020 - elifesciences.org
Efficient precision genome engineering requires high frequency and specificity of integration
at the genomic target site. Here, we describe a set of resources to streamline reporter gene …

Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and …

LE Schultz, JA Haltom, MP Almeida… - Disease models & …, 2018 - journals.biologists.com
In this study, we used comparative genomics and developmental genetics to identify
epigenetic regulators driving oncogenesis in a zebrafish retinoblastoma 1 (rb1) somatic-targeting …

GeneWeld: a method for efficient targeted integration directed by short homology

…, Z Ming, A Wehmeier, CS Mikelson, JA Haltom… - BioRxiv, 2018 - biorxiv.org
Choices for genome engineering and integration involve high efficiency but little or no target
specificity or high specificity but low activity. Here, we describe a targeted integration …

A pan-tissue, pan-disease compendium of human orphan genes

U Singh, JA Haltom, JW Guarnieri, J Li, A Seetharam… - bioRxiv, 2024 - biorxiv.org
Species-specific genes are ubiquitous in evolution, with functions ranging from prey paralysis
to survival in subzero temperatures. Because they are typically expressed under limited …

Unraveling the genomic landscape of ancestry and disease with gene expression data

JA Haltom - 2023 - search.proquest.com
The field of disease genomics aims to better understand the molecular mechanisms that
underlie a disease and allow it to propagate. Additionally, is it well known that diseases …

SARS-CoV-2 Orphan Gene ORF10 Contributes to More Severe COVID-19 Disease (preprint)

JA Haltom, NS Trovao, J Guarnieri, V Pan, U Singh… - 2023 - pesquisa.bvsalud.org
The orphan gene of SARS-CoV-2, ORF10, is the least studied gene in the virus responsible
for the COVID-19 pandemic. Recent experimentation indicated ORF10 expression …

The use of bioinformatics and current genome editing tools in investigating zebrafish RB1-deficient brain tumors

JA Haltom - 2018 - search.proquest.com
This dissertation focuses on the analysis of RNA-Seq data in the context of cancer, ultimately
leading to the identification of candidate genes to target for downstream analysis of their …

Tissue-Driven Hypothesis of Transcriptome Evolution: An Update

HT Hallmark, JA Haltom, X Gu - bioRxiv, 2016 - biorxiv.org
In past decade, many reports have demonstrated that tissues in multi-cellular organisms
may play important roles to shape the pattern of genome evolution. The tissue-driven …

Lethal COVID-19 Associates With RAAS-Induced Inflammation For Multiple Organ Damage Including Mediastinal Lymph Nodes

JW Guarnieri, MJ Topper, K Beigel, JA Haltom… - bioRxiv, 2023 - biorxiv.org
Lethal COVID-19 outcomes are most often attributed to classic cytokine storm and attendant
excessive immune signaling. We re-visit this question using RNA sequencing in …

Expression profiling of zebrafish rb1-neuroectodermal-like brain tumors: A new model of CNS PNETs

MA McGrail, SL Solin, JA Haltom, LE Schultz, JJ Essner… - Cancer Research, 2016 - AACR
We examined the gene expression signature of zebrafish brain tumors induced by somatic
inactivation of the retinoblastoma tumor suppressor rb1 to determine the similarity with human …