CRISPR-Cas systems allow bacteria and archaea to acquire sequence-specific immunity
against selfish genetic elements such as viruses and plasmids, by specific degradation of …

Halophilic archaea use a fusion-based mating system for lateral gene transfer across cells,
yet the molecular mechanisms involved remain unknown. Previous work implied that cell …

Inteins are parasitic genetic elements that excise themselves at the protein level by self-splicing,
allowing the formation of functional, nondisrupted proteins. Many inteins contain a …

CRISPR–Cas systems provide prokaryotes with sequence-specific immunity against viruses
and plasmids based on DNA acquired from these invaders, known as spacers. Surprisingly, …

Research on Archaea’s secondary metabolites is still lagging behind that of Bacteria and
Eukarya. Our goal was to contribute to this knowledge gap by analyzing the lanthipeptide's …

Haloferax volcanii is, to our knowledge, the only prokaryote known to tolerate CRISPR-Cas–mediated
damage to its genome in the WT background; the resulting cleavage of the …

Inteins are mobile genetic elements that invade conserved genes across all domains of life
and viruses. In some instances, a single gene will have several intein insertion sites. In …

CRISPR-Cas systems provide heritable acquired immunity against viruses to archaea and
bacteria. Cas3 is a CRISPR-associated protein that is common to all Type I systems, …

The study of allele-specific expression (ASE) in interspecific hybrids has played a central
role in our understanding of a wide range of phenomena, including genomic imprinting, X-…

In some extreme environments, archaeal cells have been shown to have chronic viral infections,
and such infections are well-tolerated by the hosts and may potentially protect against …