Background Butyrate, a short‐chain fatty acid, is a main end‐product of intestinal microbial
fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal …

Recently, there has been an increasing interest in the development and characterization of
patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain …

Recent advances in sequencing techniques that measure nascent transcripts and that
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

Fusarium species are among the most important phytopathogenic and toxigenic fungi. To
understand the molecular underpinnings of pathogenicity in the genus Fusarium, we …

Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based
cohort shows relations between the microbiome and 126 exogenous and intrinsic host …

Metastatic disease remains the primary cause of death for patients with breast cancer. The
different steps of the metastatic cascade rely on reciprocal interactions between cancer cells …

The application of concrete is rapidly increasing worldwide and therefore the development
of sustainable concrete is urgently needed for environmental reasons. As presently about 7% …

Inheritance of one defective BRCA2 allele predisposes humans to breast cancer. To establish
a mouse model for BRCA2-associated breast cancer, we generated mouse conditional …

To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …