Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Ubiquitination is the hallmark of protein degradation by the 26S proteasome. However, the
proteasome is limited in its capacity to degrade oligomeric and aggregated proteins. Removal …

The papain-like protease PLpro is an essential coronavirus enzyme that is required for
processing viral polyproteins to generate a functional replicase complex and enable viral spread …

Selective autophagy can be mediated via receptor molecules that link specific cargoes to
the autophagosomal membranes decorated by ubiquitin-like microtubule-associated protein …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms. Moreover…

Autophagy is the cellular homeostatic pathway that delivers large cytosolic materials for
degradation in the lysosome. Recent evidence indicates that autophagy mediates selective …

Autophagy is a catabolic process where cytosolic cellular components are delivered to the
lysosome for degradation. Recent studies have indicated the existence of specific receptors, …

THE mechanisms by which mitogenic G-protein-coupled receptors activate the MAP kinase
signalling pathway are poorly understood. Candidate protein tyrosine kinases that link G-…

Ubiquitin (Ub) is a small protein modifier that regulates many biological processes, including
gene transcription, cell‐cycle progression, DNA repair, apoptosis, virus budding and …