The ‘high mobility group’ HMGA protein family consists of four members: HMGA1a, HMGA1b
and HMGA1c, which result from translation of alternative spliced forms of one gene and …

Anti-TNF antibodies have acquired a prominent place in the management of IBD (including
Crohn's disease and ulcerative colitis), rheumatologic conditions (such as rheumatoid arthritis…

Inflammatory bowel disease and Parkinson’s disease are chronic progressive disorders that
mainly affect different organs: the gut and brain, respectively. Accumulating evidence has …

Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

Background Crohn's disease and ulcerative colitis are the two major forms of inflammatory
bowel disease; treatment strategies have historically been determined by this binary …

Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect
millions of people worldwide. Genome-wide association studies have identified 200 …

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to
fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation 1 , 2 , …

Objective Through genome-wide association scans and meta-analyses thereof, over 70
genetic loci (Crohn's disease (CD) single nucleotide polymorphisms (SNPs)) are significantly …

Background Antimicrobial peptides (AMPs) protect the host intestinal mucosa against
microorganisms. Abnormal expression of defensins was shown in inflammatory bowel disease (IBD…

Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn’s disease (CD). However, as with all complex diseases, robust identification of the …