Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a
methylene linkage between the 2′-oxygen and the 4′-carbon. This conformation restriction …

Antisense oligonucleotides have the potential to make revolutionary contributions to basic
science and medicine. Oligonucleotides can bind mRNA and inhibit translation. Because they …

The influence of genetic variation on invasion success has captivated researchers since the
start of the field of invasion genetics 50 years ago. We review the history of work on this …

A survey of aphelenchid nematodes (Nematoda: Aphelenchida) associated with maritime
pine, Pinus pinaster, was conducted in Portugal in 1996 and 1999. A Bursaphelenchus …

Through phylogeny reconstruction we identified 49 genes with a single copy in man, mouse,
and chicken, one or two copies in the tetraploid frog Xenopus laevis, and two copies in …

Recently, digital image correlation as a tool for surface deformation measurements has
found widespread use and acceptance in the field of experimental mechanics. The method is …

RNA interference (RNAi) is proving to be a robust and versatile technique for controlling
gene expression in mammalian cells. To fully realize its potential in vivo, however, it may be …

The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of
lobe-finned fish was thought to have become extinct 70 million years ago. The modern …

Although originally developed for the military, the Global Positioning System (GPS) has
proven invaluable for a multitude of civilian applications. Each application demands specific …

There are approximately 25 000 species in the division Teleostei and most are believed to
have arisen during a relatively short period of time ca. 200 Myr ago. The discovery of ‘extra’ …