Base editing — the introduction of single-nucleotide variants (SNVs) into DNA or RNA in living
cells — is one of the most recent advances in the field of genome editing. As around half …

The microbial adaptive immune system CRISPR mediates defense against foreign genetic
elements through two classes of RNA-guided nuclease effectors. Class 1 effectors utilize multi…

The RNA-guided endonuclease Cas9 is a versatile genome-editing tool with a broad range
of applications from therapeutics to functional annotation of genes. Cas9 creates double-…

INTRODUCTION Almost all archaea and about half of bacteria possess clustered regularly
interspaced short palindromic repeat (CRISPR)–CRISPR-associated genes (Cas) adaptive …

The foundational adenine base editors (for example, ABE7.10) enable programmable A•T to
G•C point mutations but editing efficiencies can be low at challenging loci in primary human …

Cpf1 is an RNA-guided endonuclease of a type V CRISPR-Cas system that has been recently
harnessed for genome editing. Here, we report the crystal structure of Acidaminococcus sp…

… AAS, with help from KZ and NKP, led the design and implementation of the CRISPR
discovery pipeline. AAS also performed screening experiments and computational analysis and …

Autism spectrum disorder (ASD) is a heterogeneous disease, but genetically defined models
can provide an entry point to studying the molecular underpinnings of this disorder. We …

Since the initial reports describing CRISPR-Cas9, labs across the globe have leveraged this
valuable gene editing tool to alter the genomes of living cells. With the goal of generating …

Base editors are fusions of a deaminase and CRISPR-Cas ribonucleoprotein that allow
programmable installment of transition mutations without double-strand DNA break intermediates…