User profiles for I. M. Kaplow

Irene M. Kaplow

Lane Postdoctoral Fellow, Carnegie Mellon University
Verified email at alum.mit.edu
Cited by 733

Evolutionary constraint and innovation across hundreds of placental mammals

MJ Christmas, IM Kaplow, DP Genereux, MX Dong… - Science, 2023 - science.org
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Population-specific neuromodulation prolongs therapeutic benefits of deep brain stimulation

TA Spix, S Nanivadekar, N Toong, IM Kaplow, BR Isett… - Science, 2021 - science.org
Symptoms of neurological diseases emerge through the dysfunction of neural circuits
whose diffuse and intertwined architectures pose serious challenges for delivering therapies. …

Mammalian evolution of human cis-regulatory elements and transcription factor binding sites

…, GM Hughes, J Johnson, D Juan, IM Kaplow… - Science, 2023 - science.org
Understanding the regulatory landscape of the human genome is a long-standing objective
of modern biology. Using the reference-free alignment across 241 mammalian genomes …

[HTML][HTML] Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements

…, AE Trevino, K Spees, D Yao, IM Kaplow… - Nature …, 2019 - nature.com
Pooled CRISPR-Cas9 screens are a powerful method for functionally characterizing regulatory
elements in the non-coding genome, but off-target effects in these experiments have not …

Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements

…, VA Shvareva, A Rakuljic, MB Ji, NS Bhat, IM Kaplow… - Science, 2024 - science.org
Vocal production learning is a convergently evolved trait in vertebrates. To identify brain
genomic elements associated with mammalian vocal learning, we integrated genomic, …

Relating enhancer genetic variation across mammals to complex phenotypes using machine learning

IM Kaplow, AJ Lawler, DE Schäffer, C Srinivasan… - Science, 2023 - science.org
Protein-coding differences between species often fail to explain phenotypic diversity, suggesting
the involvement of genomic elements that regulate gene expression such as enhancers…

Addiction-associated genetic variants implicate brain cell type-and region-specific cis-regulatory elements in addiction neurobiology

…, M Kleyman, AR Brown, IM Kaplow… - Journal of …, 2021 - Soc Neuroscience
Recent large genome-wide association studies have identified multiple confident risk loci
linked to addiction-associated behavioral traits. Most genetic variants linked to addiction-…

A pooling-based approach to mapping genetic variants associated with DNA methylation

IM Kaplow, JL MacIsaac, SM Mah, LM McEwen… - Genome …, 2015 - genome.cshlp.org
DNA methylation is an epigenetic modification that plays a key role in gene regulation.
Previous studies have investigated its genetic basis by mapping genetic variants that are …

Machine learning sequence prioritization for cell type-specific enhancer design

…, AR Brown, N Shin, Y Kim, N Toong, IM Kaplow… - Elife, 2022 - elifesciences.org
Recent discoveries of extreme cellular diversity in the brain warrant rapid development of
technologies to access specific cell populations within heterogeneous tissue. Available …

HALPER facilitates the identification of regulatory element orthologs across species

X Zhang, IM Kaplow, M Wirthlin, TY Park… - …, 2020 - academic.oup.com
Diverse traits have evolved through cis-regulatory changes in genome sequence that
influence the magnitude, timing and cell type-specificity of gene expression. Advances in high-…