User profiles for I. L. Weissman

Irving Weissman

Director, Institute of Stem Cell Biology and Regenerative Medicine
Verified email at stanford.edu
Cited by 246259

[PDF][PDF] Stem cells: units of development, units of regeneration, and units in evolution

IL Weissman - cell, 2000 - cell.com
Stem cells are not only units of biological organization, a clonal level are restricted to give
rise to T lymphocytes, responsible for the development and the regeneration B lymphocytes, …

Stem cells, cancer, and cancer stem cells

T Reya, SJ Morrison, MF Clarke, IL Weissman - nature, 2001 - nature.com
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic
system has given way to the prospective isolation of several tissue-specific stem and …

Cancer stem cells—perspectives on current status and future directions: AACR Workshop on cancer stem cells

…, CHM Jamieson, DL Jones, J Visvader, IL Weissman… - Cancer research, 2006 - AACR
A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell
model for tumor development and progression. The meeting participants were charged with …

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

K Akashi, D Traver, T Miyamoto, IL Weissman - Nature, 2000 - nature.com
… Because the expression of the interleukin-7 receptor α-chain (IL-7Rα) marks the CLPs and
other downstream lymphoid progenitors 3,4 , we searched the IL-7Rα - fraction of murine …

[HTML][HTML] Identification of clonogenic common lymphoid progenitors in mouse bone marrow

M Kondo, IL Weissman, K Akashi - Cell, 1997 - cell.com
… Because of the pivotal role of the IL-7R-mediated signals in lymphoid development, we …
marrow using IL-7Rα expression as a marker. We demonstrated a newly identified Lin − IL-7R + …

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

…, MJ Kaplan, P Dalerba, IL Weissman… - Proceedings of the …, 2007 - National Acad Sciences
Like many epithelial tumors, head and neck squamous cell carcinoma (HNSCC) contains a
heterogeneous population of cancer cells. We developed an immunodeficient mouse model …

Epigenetic memory in induced pluripotent stem cells

…, R Jaenisch, R Weissleder, SH Orkin, IL Weissman… - Nature, 2010 - nature.com
Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult
cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. …

Purification and characterization of mouse hematopoietic stem cells

GJ Spangrude, S Heimfeld, IL Weissman - Science, 1988 - science.org
Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of
phenotypic markers. These cells can proliferate and differentiate with approximately unit …

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

…, L Osborne, X Wang, M Finegold, IL Weissman… - Nature medicine, 2000 - nature.com
The characterization of hepatic progenitor cells is of great scientific and clinical interest. Here
we report that intravenous injection of adult bone marrow cells in the FAH−/− mouse, an …

A role for Wnt signalling in self-renewal of haematopoietic stem cells

…, DC Scherer, K Willert, L Hintz, R Nusse, IL Weissman - Nature, 2003 - nature.com
Haematopoietic stem cells (HSCs) have the ability to renew themselves and to give rise to all
lineages of the blood; however, the signals that regulate HSC self-renewal remain unclear. …