User profiles for I. H. Cheeseman
Ian CheesemanTexas biomedical research institute Verified email at txbiomedgenetics.org Cited by 2450 |
A major genome region underlying artemisinin resistance in malaria
IH Cheeseman, BA Miller, S Nair, S Nkhoma, A Tan… - science, 2012 - science.org
… Knowing that antimalarial drug resistance is characterized by selective sweeps and reduced
diversity around resistance mutations, Cheeseman et al. (p. 79) looked for signatures of …
diversity around resistance mutations, Cheeseman et al. (p. 79) looked for signatures of …
[HTML][HTML] Distinct Roles for FOXP3+ and FOXP3− CD4+ T Cells in Regulating Cellular Immunity to Uncomplicated and Severe Plasmodium falciparum Malaria
…, S Jayasooriya, IH Cheeseman… - PLoS …, 2009 - journals.plos.org
Failure to establish an appropriate balance between pro- and anti-inflammatory immune
responses is believed to contribute to pathogenesis of severe malaria. To determine whether …
responses is believed to contribute to pathogenesis of severe malaria. To determine whether …
[HTML][HTML] Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites
…, LB Stewart, ME Deerhake, IH Cheeseman… - PLoS …, 2012 - journals.plos.org
Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading
to identifiable signatures of balancing selection. To comprehensively survey for genes under …
to identifiable signatures of balancing selection. To comprehensively survey for genes under …
[HTML][HTML] Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1
…, U D'Alessandro, D Kwiatkowski, IH Cheeseman… - Nature …, 2023 - nature.com
Malaria parasites break down host haemoglobin into peptides and amino acids in the digestive
vacuole for export to the parasite cytoplasm for growth: interrupting this process is central …
vacuole for export to the parasite cytoplasm for growth: interrupting this process is central …
[HTML][HTML] Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance
… Many of the same longitudinal samples were examined by Cheeseman et al. [47] using a
lower resolution targeted SNP genotyping approach in a study that initially identified the …
lower resolution targeted SNP genotyping approach in a study that initially identified the …
Close kinship within multiple-genotype malaria parasite infections
SC Nkhoma, S Nair, IH Cheeseman… - … of the Royal …, 2012 - royalsocietypublishing.org
Malaria infections containing multiple parasite genotypes are ubiquitous in nature, and play
a central role in models of recombination, intra-host dynamics, virulence, sex ratio, immunity …
a central role in models of recombination, intra-host dynamics, virulence, sex ratio, immunity …
Population parameters underlying an ongoing soft sweep in Southeast Asian malaria parasites
…, S Nair, M McDew-White, IH Cheeseman… - Molecular biology …, 2017 - academic.oup.com
Multiple kelch13 alleles conferring artemisinin resistance (ART-R) are currently spreading
through Southeast Asian malaria parasite populations, providing a unique opportunity to …
through Southeast Asian malaria parasite populations, providing a unique opportunity to …
Single-cell genomics for dissection of complex malaria infections
Most malaria infections contain complex mixtures of distinct parasite lineages. These
multiple-genotype infections (MGIs) impact virulence evolution, drug resistance, intra-host dynamics…
multiple-genotype infections (MGIs) impact virulence evolution, drug resistance, intra-host dynamics…
Plasmodium falciparum genetic crosses in a humanized mouse model
Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium
falciparum are a powerful tool for identifying genes controlling drug resistance and other …
falciparum are a powerful tool for identifying genes controlling drug resistance and other …
[PDF][PDF] Co-transmission of related malaria parasite lineages shapes within-host parasite diversity
…, SA Ward, TJC Anderson, IH Cheeseman - Cell host & …, 2020 - cell.com
In high-transmission regions, we expect parasite lineages within complex malaria infections
to be unrelated due to parasite inoculations from different mosquitoes. This project was …
to be unrelated due to parasite inoculations from different mosquitoes. This project was …