User profiles for I. H. Cheeseman

Ian Cheeseman

Texas biomedical research institute
Verified email at txbiomedgenetics.org
Cited by 2450

A major genome region underlying artemisinin resistance in malaria

IH Cheeseman, BA Miller, S Nair, S Nkhoma, A Tan… - science, 2012 - science.org
… Knowing that antimalarial drug resistance is characterized by selective sweeps and reduced
diversity around resistance mutations, Cheeseman et al. (p. 79) looked for signatures of …

[HTML][HTML] Distinct Roles for FOXP3+ and FOXP3 CD4+ T Cells in Regulating Cellular Immunity to Uncomplicated and Severe Plasmodium falciparum Malaria

…, S Jayasooriya, IH Cheeseman… - PLoS …, 2009 - journals.plos.org
Failure to establish an appropriate balance between pro- and anti-inflammatory immune
responses is believed to contribute to pathogenesis of severe malaria. To determine whether …

[HTML][HTML] Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites

…, LB Stewart, ME Deerhake, IH Cheeseman… - PLoS …, 2012 - journals.plos.org
Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading
to identifiable signatures of balancing selection. To comprehensively survey for genes under …

[HTML][HTML] Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

…, U D'Alessandro, D Kwiatkowski, IH Cheeseman… - Nature …, 2023 - nature.com
Malaria parasites break down host haemoglobin into peptides and amino acids in the digestive
vacuole for export to the parasite cytoplasm for growth: interrupting this process is central …

[HTML][HTML] Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance

GC Cerqueira, IH Cheeseman, SF Schaffner, S Nair… - Genome biology, 2017 - Springer
… Many of the same longitudinal samples were examined by Cheeseman et al. [47] using a
lower resolution targeted SNP genotyping approach in a study that initially identified the …

Close kinship within multiple-genotype malaria parasite infections

SC Nkhoma, S Nair, IH Cheeseman… - … of the Royal …, 2012 - royalsocietypublishing.org
Malaria infections containing multiple parasite genotypes are ubiquitous in nature, and play
a central role in models of recombination, intra-host dynamics, virulence, sex ratio, immunity …

Population parameters underlying an ongoing soft sweep in Southeast Asian malaria parasites

…, S Nair, M McDew-White, IH Cheeseman… - Molecular biology …, 2017 - academic.oup.com
Multiple kelch13 alleles conferring artemisinin resistance (ART-R) are currently spreading
through Southeast Asian malaria parasite populations, providing a unique opportunity to …

Single-cell genomics for dissection of complex malaria infections

…, F Nosten, TJC Anderson, IH Cheeseman - Genome …, 2014 - genome.cshlp.org
Most malaria infections contain complex mixtures of distinct parasite lineages. These
multiple-genotype infections (MGIs) impact virulence evolution, drug resistance, intra-host dynamics…

Plasmodium falciparum genetic crosses in a humanized mouse model

AM Vaughan, RS Pinapati, IH Cheeseman… - Nature …, 2015 - nature.com
Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium
falciparum are a powerful tool for identifying genes controlling drug resistance and other …

[PDF][PDF] Co-transmission of related malaria parasite lineages shapes within-host parasite diversity

…, SA Ward, TJC Anderson, IH Cheeseman - Cell host & …, 2020 - cell.com
In high-transmission regions, we expect parasite lineages within complex malaria infections
to be unrelated due to parasite inoculations from different mosquitoes. This project was …