Cancer is a complex disease, driven by aberrant activity in numerous signaling pathways in
even individual malignant cells. Epigenetic changes are critical mediators of these functional …

Objective One in three pregnant women in the United States is obese. Their offspring are at
increased risk for neurodevelopmental and metabolic morbidity. Underlying molecular …

Anatomical and functional brain abnormalities begin during fetal life in Down syndrome (DS).
We hypothesize that novel prenatal treatments can be identified by targeting signaling …

… In experiments with tissues removed from rats stored at +4"C after killing, the activities of
MCC and PC decreased to maximally 70% after 9 h and to maximally 66% after 24 h (not shown…

OBJECTIVE: Amniotic fluid is a complex biological material that provides a unique window
into the developing human. Residual amniotic fluid supernatant contains cell-free fetal RNA. …

Turner syndrome is a sex chromosome aneuploidy with characteristic malformations.
Amniotic fluid, a complex biological material, could contribute to the understanding of Turner …

We have developed a method for rapid differential diagnosis of isolated or multiple
deficiencies of the 3 mitochondrial biotin-dependent carboxylases: propionyl-CoA (PCC), 3-…

Objective To analyse fetal gene expression at term using umbilical cord blood, in order to
provide insights into the effects of maternal obesity on human development. Design …

Human fetuses with Down syndrome demonstrate abnormal brain growth and reduced
neurogenesis. Despite the prenatal onset of the phenotype, most therapeutic trials have been …

Background In 2010 Colony Collapse Disorder (CCD), again devastated honey bee colonies
in the USA, indicating that the problem is neither diminishing nor has it been resolved. …