Fifteen years ago, the drive to study retroviruses was rooted principally in the traditional
goal of using animal models to understand human cancer. The historical importance of …

First brought to scientific attention as infectious cancer-causing agents nearly 80 years ago,
retroviruses are popular in contemporary biology for many reasons. (i) The virus life cycle …

… Ganem, H. E. Varmus). As our knowledge of the pathways of viral replication and gene
expression grows, it seems likely that such mutational analyses will occupy an increasingly promi …

Determining the genetic basis of cancer requires comprehensive analyses of large collections
of histopathologically well-classified primary tumours. Here we report the results of a …

… Thirty-six hours later, cells were serum-starved for 24 h and then harvested for immunoblot
analyses using anti-phosphotyrosine (p-Tyr), anti-phospho-EGFR (p-EGFR Y1092), anti-total …

… After 36 h, cells were serum-starved for 24 h, treated with gefitinib or erlotinib for 1 h, and
then harvested for immunoblot analysis using anti-p-EGFR (Y1092), anti-t-EGFR, anti-…

President Obama has announced a research initiative that aims to accelerate progress
toward a new era of precision medicine, with a near-term focus on cancers and a longer …

We have asked whether oncogenesis by the mouse mammary tumor virus (MMTV), a slowly
oncogenic retrovirus, involves integration of viral DNA within a certain region of the host …

A domain of DNA designated N-myc is amplified 20- to 140-fold in human neuroblastoma
cell lines but not in cell lines from other tumor types. N-myc has now been found to be …

… 0.3 ml were incubated at either 59 or 68 C for 48 h. Samples incubated at 59 'Cwere in 1.5 M
… mixture the rates of reassociation between chicken DNA and both cDNA, (labelled with “H) …