User profiles for H. Tutill
Helena TutillResearch Assistant, UCL Verified email at ucl.ac.uk Cited by 3272 |
[HTML][HTML] Design and validation of specific inhibitors of 17β-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in …
Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit
receptor tyrosine kinases, many of which involved in angiogenesis. Response rates vary widely…
receptor tyrosine kinases, many of which involved in angiogenesis. Response rates vary widely…
[HTML][HTML] Genomic investigations of unexplained acute hepatitis in children
…, H Tutill, N Bayzid, LM Martin Bernal, H Macpherson… - Nature, 2023 - nature.com
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis
in children have been reported worldwide, including 278 cases in the UK 1 . Here we report …
in children have been reported worldwide, including 278 cases in the UK 1 . Here we report …
Rapid whole-genome sequencing of Mycobacterium tuberculosis isolates directly from clinical samples
…, R Williams, MB McAndrew, H Tutill… - Journal of clinical …, 2015 - Am Soc Microbiol
… Prior to hybridization, eight cycles of precapture PCR were used, and ∼750 ng of amplified
product was included in each hybridization (24 h, 65C). A total of 16 cycles of postcapture …
product was included in each hybridization (24 h, 65C). A total of 16 cycles of postcapture …
Human cytomegalovirus haplotype reconstruction reveals high diversity due to superinfection and evidence of within-host recombination
Recent sequencing efforts have led to estimates of human cytomegalovirus (HCMV)
genome-wide intrahost diversity that rival those of persistent RNA viruses [Renzette N, …
genome-wide intrahost diversity that rival those of persistent RNA viruses [Renzette N, …
17β‐hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone‐dependent breast cancer
… Separation of 3 H-E2 from 3 H-E1 was achieved using thin layer chromatography (TLC) in …
v/v and the production of 3 H-E2 was calculated from the 3 H counts detected and recovery of …
v/v and the production of 3 H-E2 was calculated from the 3 H counts detected and recovery of …
The development of steroid sulfatase inhibitors for hormone‐dependent cancer therapy
… In the present investigation, significant STS activity (41.5 ± 3.5 fmol/20 h/10 6 cells) was
detected in LNCaP cells, confirming the previous results of Selcer. In these AR-positive cells, …
detected in LNCaP cells, confirming the previous results of Selcer. In these AR-positive cells, …
[HTML][HTML] Whole-genome enrichment and sequencing of Chlamydia trachomatisdirectly from clinical samples
Background Chlamydia trachomatis is a pathogen of worldwide importance, causing more
than 100 million cases of sexually transmitted infections annually. Whole-genome …
than 100 million cases of sexually transmitted infections annually. Whole-genome …
Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1
…, DS Fischer, N Vicker, A Smith, HJ Tutill… - Journal of medicinal …, 2006 - ACS Publications
… In this case, however, no 6-oxo product was observed ( 1 H NMR showed no C4−H shift
associated with deshielding by the new carbonyl group). The use of chromium hexacarbonyl …
associated with deshielding by the new carbonyl group). The use of chromium hexacarbonyl …
[HTML][HTML] Detection of low frequency multi-drug resistance and novel putative maribavir resistance in immunocompromised pediatric patients with cytomegalovirus
…, J Simmonds, S Nicolaou, HJ Tutill… - Frontiers in …, 2016 - frontiersin.org
… Patients H and M developed single fixed resistance mutations and recovered from HCMV
disease. ORF locations of each mutation are Table 1. Red arrows: samples deep sequenced …
disease. ORF locations of each mutation are Table 1. Red arrows: samples deep sequenced …
Islands of linkage in an ocean of pervasive recombination reveals two-speed evolution of human cytomegalovirus genomes
Human cytomegalovirus (HCMV) infects most of the population worldwide, persisting
throughout the host's life in a latent state with periodic episodes of reactivation. While typically …
throughout the host's life in a latent state with periodic episodes of reactivation. While typically …