User profiles for H. Tutill

Helena Tutill

Research Assistant, UCL
Verified email at ucl.ac.uk
Cited by 3272

[HTML][HTML] Design and validation of specific inhibitors of 17β-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in …

JM Day, HJ Tutill, A Purohit… - Endocrine-related …, 2008 - erc.bioscientifica.com
Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit
receptor tyrosine kinases, many of which involved in angiogenesis. Response rates vary widely…

[HTML][HTML] Genomic investigations of unexplained acute hepatitis in children

…, H Tutill, N Bayzid, LM Martin Bernal, H Macpherson… - Nature, 2023 - nature.com
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis
in children have been reported worldwide, including 278 cases in the UK 1 . Here we report …

Rapid whole-genome sequencing of Mycobacterium tuberculosis isolates directly from clinical samples

…, R Williams, MB McAndrew, H Tutill… - Journal of clinical …, 2015 - Am Soc Microbiol
… Prior to hybridization, eight cycles of precapture PCR were used, and ∼750 ng of amplified
product was included in each hybridization (24 h, 65C). A total of 16 cycles of postcapture …

Human cytomegalovirus haplotype reconstruction reveals high diversity due to superinfection and evidence of within-host recombination

…, JM Bryant, DP Depledge, H Tutill… - Proceedings of the …, 2019 - National Acad Sciences
Recent sequencing efforts have led to estimates of human cytomegalovirus (HCMV)
genome-wide intrahost diversity that rival those of persistent RNA viruses [Renzette N, …

17β‐hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone‐dependent breast cancer

JM Day, PA Foster, HJ Tutill… - … journal of cancer, 2008 - Wiley Online Library
… Separation of 3 H-E2 from 3 H-E1 was achieved using thin layer chromatography (TLC) in …
v/v and the production of 3 H-E2 was calculated from the 3 H counts detected and recovery of …

The development of steroid sulfatase inhibitors for hormone‐dependent cancer therapy

JM Day, A Purohit, HJ Tutill, PA Foster… - Annals of the New …, 2009 - Wiley Online Library
… In the present investigation, significant STS activity (41.5 ± 3.5 fmol/20 h/10 6 cells) was
detected in LNCaP cells, confirming the previous results of Selcer. In these AR-positive cells, …

[HTML][HTML] Whole-genome enrichment and sequencing of Chlamydia trachomatisdirectly from clinical samples

MT Christiansen, AC Brown, S Kundu, HJ Tutill… - BMC infectious …, 2014 - Springer
Background Chlamydia trachomatis is a pathogen of worldwide importance, causing more
than 100 million cases of sexually transmitted infections annually. Whole-genome …

Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1

…, DS Fischer, N Vicker, A Smith, HJ Tutill… - Journal of medicinal …, 2006 - ACS Publications
… In this case, however, no 6-oxo product was observed ( 1 H NMR showed no C4−H shift
associated with deshielding by the new carbonyl group). The use of chromium hexacarbonyl …

[HTML][HTML] Detection of low frequency multi-drug resistance and novel putative maribavir resistance in immunocompromised pediatric patients with cytomegalovirus

…, J Simmonds, S Nicolaou, HJ Tutill… - Frontiers in …, 2016 - frontiersin.org
… Patients H and M developed single fixed resistance mutations and recovered from HCMV
disease. ORF locations of each mutation are Table 1. Red arrows: samples deep sequenced …

Islands of linkage in an ocean of pervasive recombination reveals two-speed evolution of human cytomegalovirus genomes

…, AC Brown, MT Christiansen, HJ Tutill… - Virus …, 2016 - academic.oup.com
Human cytomegalovirus (HCMV) infects most of the population worldwide, persisting
throughout the host's life in a latent state with periodic episodes of reactivation. While typically …