Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in
the world and has received considerable attention regarding health risks and benefits. We …

Background Ethnic disparities in cardiovascular morbidity and mortality are widely documented
in the literature. Recently, research has shown that decreased parasympathetic cardiac …

Insulin resistance often occurs with dyslipidemia as part of the metabolic syndrome and the
current dominant paradigm is that insulin resistance leads to dyslipidemia. However, …

Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Objective Twin concordance data for rheumatoid arthritis (RA) on their own provide only
limited insight into the relative genetic and environmental contribution to the disease. We …

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease.
We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …

… Let denote the narrow-sense heritability (h 2 ) for a complex trait captured by the sequence
… replicates was not significantly different from the h 2 parameter used for simulation. We could …