Aims To appraise the clinical and genetic evidence that low-density lipoproteins (LDLs)
cause atherosclerotic cardiovascular disease (ASCVD). Methods and results We assessed …

… Fernandez-Friera L, Penalvo JL, Fernandez-Ortiz A, Ibanez B, Lopez-Melgar B, Laclaustra M,
Oliva B, Mocoroa A, Mendiguren J, Martinez de Vega V, Garcia L, Molina J, Sanchez-Gonzalez …

Angiotensin-converting enzyme (ACE) is primarily localized (>90%) in various tissues and
organs, most notably on the endothelium but also within parenchyma and inflammatory cells. …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Background Modern genotyping platforms permit a systematic search for inherited components
of complex diseases. We performed a joint analysis of two genomewide association …

Background The natural history, management, and outcome of takotsubo (stress)
cardiomyopathy are incompletely understood. Methods The International Takotsubo Registry, a …

We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

We conducted a genome-wide association study testing single nucleotide polymorphisms (SNPs)
and copy number variants (CNVs) for association with early-onset myocardial …

Background Mortality and morbidity are higher among patients with atrial fibrillation and heart
failure than among those with heart failure alone. Catheter ablation for atrial fibrillation has …

Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …