User profiles for H. Houlden

Henry Houlden

Prof Neurology and Neurogenetics
Verified email at ucl.ac.uk
Cited by 59118

The neuropathology, pathophysiology and genetics of multiple system atrophy

…, YT Asi, A Sailer, AJ Lees, H Houlden… - Neuropathology and …, 2012 - Wiley Online Library
… Professor Houlden is supported by the Medical Research Council (MRC), Ataxia UK and
The Wellcome Trust. Part of this work was undertaken at UCLH/UCL who received a proportion …

The genetics and neuropathology of Parkinson's disease

H Houlden, AB Singleton - Acta neuropathologica, 2012 - Springer
There has been tremendous progress toward understanding the genetic basis of Parkinson’s
disease and related movement disorders. We summarize the genetic, clinical and …

Clinical implications of genetic advances in Charcot–Marie–Tooth disease

AM Rossor, JM Polke, H Houlden… - Nature Reviews …, 2013 - nature.com
Charcot–Marie–Tooth disease (CMT) refers to a group of inherited neuropathies with a broad
range of phenotypes, inheritance patterns and causative genes. The number of disease …

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

…, P Heutink, H Chen, NW Wood, H Houlden, H Payami… - Nature …, 2014 - nature.com
We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six …

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

…, CL Lendon, P Rizzu, M Baker, S Froelich, H Houlden… - Nature, 1998 - nature.com
… Cells were collected 24 h post-transfection and RNA prepared using the Trizol reagent (Life
Technologies). First-strand synthesis and nested PCR were done using reagents supplied …

Genome-wide association study reveals genetic risk underlying Parkinson's disease

…, M Bonin, MA Nalls, T Illig, C Gieger, H Houlden… - Nature …, 2009 - nature.com
We performed a genome-wide association study (GWAS) in 1,713 individuals of European
ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases …

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

…, J Hoenicka, P Holmans, H Houlden… - The Lancet …, 2019 - thelancet.com
Background Genome-wide association studies (GWAS) in Parkinson's disease have increased
the scope of biological knowledge about the disease over the past decade. We aimed to …

[HTML][HTML] Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

…, H Houlden, JD Rohrer, KE Morrison, H Pall… - The Lancet …, 2012 - thelancet.com
Background We aimed to accurately estimate the frequency of a hexanucleotide repeat
expansion in C9orf72 that has been associated with a large proportion of cases of amyotrophic …

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

M Mullan, F Crawford, K Axelman, H Houlden, L Lilius… - Nature …, 1992 - nature.com
Mutations at codon 717 in exon 17 of the β–amyloid precursor protein (APP) gene have
previously been shown to segregate with early onset Alzheimer's disease in some families. We …

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

MC Chartier-Harlin, F Crawford, H Houlden, A Warren… - Nature, 1991 - nature.com
A MUTATION at codon 717 of the β-amyloid precursor protein gene has been found to
cosegregate with familial Alzheimer's disease in a single family 1 . This mutation has been …