Recent breakthroughs in cancer immunotherapy and decreasing costs of high-throughput
technologies have sparked intensive research into tumour–immune cell interactions using …

We have developed ClueGO, an easy to use Cytoscape plug-in that strongly improves
biological interpretation of large lists of genes. ClueGO integrates Gene Ontology (GO) terms as …

The remarkable success of cancer therapies with immune checkpoint blockers is
revolutionizing oncology and has sparked intensive basic and translational research into the …

The Cancer Genome Atlas revealed the genomic landscapes of human cancers. In parallel,
immunotherapy is transforming the treatment of advanced cancers. Unfortunately, the …

Background The majority of individuals with acute myeloid leukemia (AML) respond to initial
chemotherapy and achieve a complete remission, yet only a minority experience long-term …

We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from bulk
RNA-sequencing data. quanTIseq was extensively validated in blood and tumor samples …

… Major differences in the enrichment of TIL subpopulations could be observed in the MSI-H,
MSS^, and the four MSS subtypes. MSI-H tumors were enriched with all CD4 and CD8 …

High mucosal and fecal concentrations of the antimicrobial siderophore-binding peptide
Lipocalin-2 (Lcn2) are observed in inflammatory bowel disease. However, Lcn2 function in …

The microstructure and properties of aluminium–zinc coated steel lap joints made by a
modified metal inert gas CMT welding–brazing process was investigated. It was found that the …

The cancer immunoediting hypothesis postulates a dual role of the immune system: protecting
the host by eliminating tumor cells, and shaping the tumor by editing its genome. Here, we …