Development of the body plan is controlled by large networks of regulatory genes. A gene
regulatory network that controls the specification of endoderm and mesoderm in the sea …

Abstract Systems biology has experienced dramatic growth in the number, size, and
complexity of computational models. To reproduce simulation results and reuse models, …

Developmental processes in complex animals are directed by a hardwired genomic regulatory
code, the ultimate function of which is to set up a progression of transcriptional regulatory …

… Brown,CT, Rust,AG, Clarke,PJC, Pan,Z., Schilstra,MJ, De Buysshcher,T., Griffin,G., Wold,BJ,
Cameron,RA, Davidson,EH and Bolouri,H. (2002) New computational approaches for …

The genomic regulatory network that controls gene expression ultimately determines form
and function in each species. The operational nature of the regulatory programming specified …

… h of LPS stimulation, and this binding declined after 2 h. ATF3 binding occurred more slowly,
with maximal binding at 4 h… not decline, and remained constant at 6 h (Fig. 3a). The binding …

Tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for
cancers that have metastasized. To determine whether the genomic alterations in a single …

… Hamid Bolouri …

We present the molecular landscape of pediatric acute myeloid leukemia (AML) and
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The COG–…

… Completion and analysis of the DNA sequence of the first model organism, H. influenza,
marked the end of our innocence; similarly, entry into the contemporary high throughput era, …