Combinatorial selection of high affinity RNA ligands to live African trypanosomes

M Homann, HU Göringer - Nucleic acids research, 1999 - academic.oup.com
African trypanosomiasis is a parasitic disease caused by a specific class of protozoan
organisms. The best-studied representative of that group is Trypanosoma brucei which is …

Post-SELEX chemical optimization of a trypanosome-specific RNA aptamer

HU Goringer, A Adler, N Forster… - … chemistry & high …, 2008 - ingentaconnect.com
African trypanosomes are the causative agent of sleeping sickness. The therapeutics used
to control and treat the disease are very ineffective and thus, the development of improved …

Lexis and grammar of mitochondrial RNA processing in trypanosomes

…, J Carnes, I Cestari, J Cruz-Reyes, HU Göringer… - Trends in …, 2020 - cell.com
Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on
health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast …

Targeting the variable surface of African trypanosomes with variant surface glycoprotein-specific, serum-stable RNA aptamers

M Lorger, M Engstler, M Homann, HU Göringer - Eukaryotic Cell, 2003 - Am Soc Microbiol
African trypanosomes cause sleeping sickness in humans and Nagana in cattle. The parasites
multiply in the blood and escape the immune response of the infected host by antigenic …

Disruption of a Gene Encoding a Novel Mitochondrial DEAD-Box Protein in Trypanosoma brucei Affects Edited mRNAs

…, AE Souza, G Nörskau, HU Göringer - Molecular and cellular …, 1997 - Taylor & Francis
… formed as described by Missel and Göringer (36). As a substrate, gRNA gA6-14 hybridized
to its cognate domain of the edited ATPase 6 mRNA was used. The uridylate deletion RNA-…

Ultrasensitive and real-time detection of proteins in blood using a potentiometric carbon-nanotube aptasensor

…, A Tweed-Kent, M Niemann, HU Göringer… - Biosensors and …, 2013 - Elsevier
Potentiometric sensing represents the preferred technique in many routine measurements
of pH and ions. Unfortunately, the simplicity of the technique has not been exploited so far in …

Cell-free prototyping of AND-logic gates based on heterogeneous RNA activators

…, M Hanst, M Vogel, J Kremer, HU Göringer… - ACS synthetic …, 2019 - ACS Publications
RNA-based devices controlling gene expression bear great promise for synthetic biology,
as they offer many advantages such as short response times and light metabolic burden …

[HTML][HTML] Annealing of RNA editing substrates facilitated by guide RNA‐binding protein gBP21

UF Müller, L Lambert, HU Göringer - The EMBO journal, 2001 - embopress.org
RNA editing within the mitochondria of African trypanosomes is characterized by the
insertion and deletion of uridylate residues into otherwise incomplete primary transcripts. The …

Uptake and intracellular transport of RNA aptamers in African trypanosomes suggest therapeutic “piggy-back” approach

M Homann, HU Göringer - Bioorganic & medicinal chemistry, 2001 - Elsevier
African trypanosomes are protozoan organisms that multiply as extracellular parasites in the
blood of humans and other mammals. The parasites escape destruction by the host immune …

Mechanism of the gBP21-mediated RNA/RNA annealing reaction: matchmaking and charge reduction

UF Müller, HU Göringer - Nucleic acids research, 2002 - academic.oup.com
… The starting DNA library and the amplification primers are described by Homann and
Göringer (30). The initial RNA transcription was performed with T7 RNA polymerase using …