User profiles for H. R. Zhou

Hongjun (Robin) Zhou

UC Santa Barbara
Verified email at lifesci.ucsb.edu
Cited by 2400

Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox

JJ Pestka, HR Zhou, Y Moon, YJ Chung - Toxicology letters, 2004 - Elsevier
Macrophages, T cells, and B cells of the immune system are central targets of deoxynivalenol
(DON) and other trichothecenes-mycotoxins that can be immunostimulatory or …

Safety of four SGLT2 inhibitors in three chronic diseases: A meta-analysis of large randomized trials of SGLT2 inhibitors

…, LL Ding, M Zhang, HR Zhou - Diabetes and Vascular …, 2021 - journals.sagepub.com
There are no relevant meta-analyses that have assessed the safety of the sodium-glucose
transporter 2 (SGLT2) inhibitors in different chronic diseases. We aimed at evaluating the …

Role of double-stranded RNA-activated protein kinase R (PKR) in deoxynivalenol-induced ribotoxic stress response

HR Zhou, AS Lau, JJ Pestka - Toxicological Sciences, 2003 - academic.oup.com
Trichothecene mycotoxins and other protein synthesis inhibitors activate mitogen-activated
protein kinase (MAPKs) via a mechanism that has been termed the “ribotoxic stress response.…

Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development

TJ Nowakowski, N Rani, M Golkaram, HR Zhou… - Nature …, 2018 - nature.com
MicroRNAs (miRNAs) regulate many cellular events during brain development by interacting
with hundreds of mRNA transcripts. However, miRNAs operate nonuniformly upon the …

A molecular signature for anastasis, recovery from the brink of apoptotic cell death

…, V Balasanyan, CM Conner, K Wong, HR Zhou… - Journal of Cell …, 2017 - rupress.org
… response genes that were induced during the first hour of anastasis were already elevated in
HR Zhou carried out the mapping of RNAseq reads. V. Balasanyan tested the cytochrome c …

Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice …

HR Zhou, Z Islam, JJ Pestka - Toxicological sciences, 2003 - academic.oup.com
Since proinflammatory cytokine mRNA expression is induced within lymphoid tissue in vivo
by the trichothecene vomitoxin (VT) in a rapid (1–2 h) and transient (4–8 h) fashion, it was …

Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck

HR Zhou, Q Jia, JJ Pestka - Toxicological Sciences, 2005 - academic.oup.com
Trichothecene mycotoxins and other translational inhibitors activate mitogen-activated protein
kinase (MAPKs) by a mechanism called the “ribotoxic stress response,” which drives both …

Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-α expression by deoxynivalenol (vomitoxin)

YJ Chung, HR Zhou, JJ Pestka - Toxicology and applied pharmacology, 2003 - Elsevier
Deoxynivalenol (DON, vomitoxin) is a trichothecene mycotoxin that potentially mediates
toxicity by upregulating proinflammatory cytokine gene expression in vitro and in vivo. The …

[HTML][HTML] NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model

XY Wang, HR Zhou, S Wang, CY Liu, GC Qin… - The journal of headache …, 2018 - Springer
Background Although the mechanism of chronic migraine (CM) is unclear, it might be
related to central sensitization and neuronal persistent hyperexcitability. The tyrosine …

Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol

HR Zhou, Z Islam, JJ Pestka - Toxicological Sciences, 2005 - academic.oup.com
… The supernatant containing fragmented DNA was digested for 1 h at 37C with RNase A (0.4
mg/ml) and then incubated for another hour at 37C with proteinase (0.4 mg/ml). DNA was …