The secosteroid hormone 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) is the major biologically
active metabolite of vitamin D 3 . (Secosteroids are those in which one of the rings has …

Several human acute myeloid leukemia cell lines were recently established. These lines
provide model systems to study the control of differentiation in human myelogenous leukemia …

A prominent phenotypic abnormality of human acute myelogenous leukemia cells is the
inability of the cells to differentiate to functional mature cells; instead, the cells are blocked at an …

Numerous large-scale genomic studies of matched tumor-normal samples have established
the somatic landscapes of most cancer types. However, the downstream analysis of data …

Myelodysplastic syndromes and related disorders (myelodysplasia) are a heterogeneous
group of myeloid neoplasms showing deregulated blood cell production with evidence of …

The innate immune system of mammals provides a rapid response to repel assaults from
numerous infectious agents including bacteria, viruses, fungi, and parasites. A major …

High-throughput DNA sequencing significantly contributed to diagnosis and prognostication
in patients with myelodysplastic syndromes (MDS). We determined the biological and …

… Müller and HP Koeffler, unpublished data) was cotransfected at a ratio of 1:4. The green
fluorescent protein-expressing cells were selected using a FACStar (Becton Dickinson) flow …

Transferrin receptor (TfR) plays a major role in cellular iron uptake through binding and
internalizing a carrier protein transferrin (Tf). We have cloned, sequenced, and mapped a human …

The development and progression of thyroid tumors is signaled by phenotype-specific
mutations of genes involved in growth control. Molecular events associated with undifferentiated …