… by an increase in extracellular [K+] (but not Na+), as though K+ ions entering the pore from
the extracellular side can destabilize the bound peptide through repulsion (Demo & Yellen, …

The voltage-gated potassium channels are the prototypical members of a family of membrane
signalling proteins. These protein-based machines have pores that pass millions of ions …

A dietary therapy for pediatric epilepsy known as the ketogenic diet has seen a revival in its
clinical use during the past decade. Although the underlying mechanism of the diet remains …

… Jurman for assistance in preparing the mutants and the transfected cells, and G. Robertson
for the cDNA clone for HERG. This work was partially supported by the National Institute of …

… , however, to explain both the permeation properties of the channel and the large voltage
dependence of block in the context ofa straightforward Eyring model for permeation (Yellen, …

… Yellen, Howard Hughes Medical Institute and the Department of Neuroscience, The Johns
… MacKinnon and G. Yellen, unpublished data. 13. The D431K mutant was expressed poorly …

NADH is a key metabolic cofactor whose sensitive and specific detection in the cytosol of
live cells has been difficult. We constructed a fluorescent biosensor of the cytosolic NADH-NAD …

The active site of voltage-activated potassium channels is a transmembrane aqueous pore
that permits ions to permeate the cell membrane in a rapid yet highly selective manner. A …

… the standard deviation for the midpoint of the g–V curve. C-type inactivation (Baukrowitz
and Yellen, 1996a, 1996b). Neither of these effects is likely to be responsible for the protection …

Voltage-activated K+ channels are a family of closely related membrane proteins that differ
in their gating behavior, conductance, and pharmacology. A prominent and physiologically …